Protective effects of ectoine on articular chondrocytes and cartilage in rats for treating osteoarthritis

Peng Li; Yong Huang; Lishuai Miao; Zhiqi Zhu; Zhanjun Shi

doi:10.1371/journal.pone.0299351

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Open Access

Peer-reviewed

Research Article

Protective effects of ectoine on articular chondrocytes and cartilage in rats for treating osteoarthritis

Peng Li ,

Contributed equally to this work with: Peng Li, Yong Huang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: lipeng8436@126.com (PL); 59114835@qq.com (ZS)

Affiliations Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China, Orthopedic Surgery Department of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People’ s Hospital of Shenzhen, Shenzhen, Guangdong, China

https://orcid.org/0000-0001-9432-2569

⨯
Yong Huang ,

Contributed equally to this work with: Peng Li, Yong Huang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Software, Writing – original draft, Writing – review & editing

Affiliation Orthopedic Surgery Department of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People’ s Hospital of Shenzhen, Shenzhen, Guangdong, China
⨯
Lishuai Miao,

Roles Data curation, Methodology, Resources, Writing – original draft

Affiliation Orthopedic Surgery Department of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People’ s Hospital of Shenzhen, Shenzhen, Guangdong, China
⨯
Zhiqi Zhu,

Roles Conceptualization, Data curation, Methodology, Writing – original draft

Affiliation Orthopedic Surgery Department of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People’ s Hospital of Shenzhen, Shenzhen, Guangdong, China
⨯
Zhanjun Shi

Roles Supervision, Writing – review & editing

* E-mail: lipeng8436@126.com (PL); 59114835@qq.com (ZS)

Affiliation Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
⨯

Protective effects of ectoine on articular chondrocytes and cartilage in rats for treating osteoarthritis

Peng Li,
Yong Huang,
Lishuai Miao,
Zhiqi Zhu,
Zhanjun Shi

Published: February 29, 2024
https://doi.org/10.1371/journal.pone.0299351

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Chondrocytes
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Cartilage
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Serine proteases
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Collagens
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Osteoarthritis
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Articular cartilage
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Reactive oxygen species
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