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Open Access
Peer-reviewed
Research Article
Halofuginone for non-hospitalized adult patients with COVID-19 a multicenter, randomized placebo-controlled phase 2 trial. The HALOS trial
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Bruno Martins Tomazini ,
Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: btomazini@hcor.com.br
Affiliations Hcor Research Institute, São Paulo (SP), Brazil, Brazilian Research in Intensive Care Network (BRICNet), São Paulo (SP), Brazil, Hospital Sírio-Libanês, São Paulo (SP), Brazil
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Lucas Tramujas,
Roles Investigation, Project administration, Validation, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Fernando Azevedo Medrado Junior,
Roles Investigation, Validation, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Samara Pinheiro do Carmo Gomes,
Roles Project administration, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Karina Leal Negrelli,
Roles Project administration, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Gabriela Souza Murinize,
Roles Data curation, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Renato Hideo Nakagawa Santos,
Roles Formal analysis, Validation, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Bruna Martins Pereira Vianna,
Roles Project administration, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Bruna Fornazieri Piotto,
Roles Project administration, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Thabata Silva Veiga,
Roles Project administration, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Bianca Rodrigues do Santos,
Roles Project administration, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Ana Clara Peneluppi Horak,
Roles Project administration, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Olivia Mora Cavalcante Lemos,
Roles Project administration, Writing – review & editing
Affiliation Hospital do Coração (HCor), São Paulo (SP), Brazil
⨯ - Marcela de Almeida Lopes,
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Beatriz Baptista Olicheski,
Roles Project administration, Writing – review & editing
Affiliation Hospital do Coração (HCor), São Paulo (SP), Brazil
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Diego Lurentt Campones,
Roles Project administration, Writing – review & editing
Affiliation Hospital do Coração (HCor), São Paulo (SP), Brazil
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Luiz Angelo Alencar Peixoto,
Roles Project administration, Writing – review & editing
Affiliation Hospital do Coração (HCor), São Paulo (SP), Brazil
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Aline dos Anjos Chaves Basilio,
Roles Project administration, Writing – review & editing
Affiliation Hospital do Coração (HCor), São Paulo (SP), Brazil
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Otavio Celso Eluf Gebara,
Roles Investigation, Project administration, Writing – review & editing
Affiliation Hospital Santa Paula, São Paulo (SP), Brazil
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Ana Tarina Alvarez Lopes,
Roles Project administration, Writing – review & editing
Affiliation Hospital Santa Paula, São Paulo (SP), Brazil
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Humberto Saconato,
Roles Investigation, Project administration, Writing – review & editing
Affiliation Hospital Santa Paula, São Paulo (SP), Brazil
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Nanci Valeis,
Roles Project administration, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Tamiris Abait Miranda,
Roles Project administration, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Ligia Nasi Laranjeira,
Roles Project administration, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Eliana Vieira Santucci,
Roles Data curation, Validation, Writing – review & editing
Affiliation Hcor Research Institute, São Paulo (SP), Brazil
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Aaron Foster Carlin,
Roles Conceptualization, Resources, Supervision, Validation, Writing – review & editing
Affiliation Departments of Pathology and Medicine, University of California, San Diego, La Jolla, California, United States of America
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Jeffrey David Esko,
Roles Conceptualization, Resources, Supervision, Validation, Writing – review & editing
Affiliation Department of Cellular and Molecular Medicine and Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, United States of America
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Phillip Leo Stephan Marie Gordts,
Roles Conceptualization, Resources, Supervision, Validation, Writing – review & editing
Affiliation Department of Medicine, and Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, United States of America
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Sotirios Tsimikas,
Roles Conceptualization, Resources, Supervision, Validation, Writing – review & editing
Affiliation Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California San Diego, La Jolla, California, United States of America
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Alexandre Biasi Cavalcanti
Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing
Affiliations Hcor Research Institute, São Paulo (SP), Brazil, Brazilian Research in Intensive Care Network (BRICNet), São Paulo (SP), Brazil
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Halofuginone for non-hospitalized adult patients with COVID-19 a multicenter, randomized placebo-controlled phase 2 trial. The HALOS trial
- Bruno Martins Tomazini,
- Lucas Tramujas,
- Fernando Azevedo Medrado Junior,
- Samara Pinheiro do Carmo Gomes,
- Karina Leal Negrelli,
- Gabriela Souza Murinize,
- Renato Hideo Nakagawa Santos,
- Bruna Martins Pereira Vianna,
- Bruna Fornazieri Piotto,
- Thabata Silva Veiga
- Published: February 23, 2024
- https://doi.org/10.1371/journal.pone.0299197