IL-17A deficiency inhibits lung cancer-induced osteoclastogenesis by promoting apoptosis of osteoclast precursor cells

Hongkai Wang; Hao Tang; Shujie Yuan; Chuntao Liang; Yuanxin Li; Shida Zhu; Kai Chen

doi:10.1371/journal.pone.0299028

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Open Access

Peer-reviewed

Research Article

IL-17A deficiency inhibits lung cancer-induced osteoclastogenesis by promoting apoptosis of osteoclast precursor cells

Hongkai Wang ,

Roles Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: wanghongkai1983@163.com

Affiliations Department of Orthopedics, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China, Guangxi Key Laboratory of Metabolic Reprogramming and Intelligent Medical Engineering for Chronic Diseases, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China

https://orcid.org/0000-0001-6225-7985

⨯
Hao Tang,

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliations Department of Orthopedics, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China, Guangxi Key Laboratory of Metabolic Reprogramming and Intelligent Medical Engineering for Chronic Diseases, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China
⨯
Shujie Yuan,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Department of Orthopedics, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China
⨯
Chuntao Liang,

Roles Methodology, Writing – review & editing

Affiliation Department of Orthopedics, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China
⨯
Yuanxin Li,

Roles Software, Validation

Affiliation Department of Orthopedics, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China
⨯
Shida Zhu,

Roles Writing – review & editing

Affiliation Department of Orthopedics, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China
⨯
Kai Chen

Roles Software, Writing – review & editing

Affiliation Department of Orthopedics, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China
⨯

IL-17A deficiency inhibits lung cancer-induced osteoclastogenesis by promoting apoptosis of osteoclast precursor cells

Hongkai Wang,
Hao Tang,
Shujie Yuan,
Chuntao Liang,
Yuanxin Li,
Shida Zhu,
Kai Chen

Published: February 23, 2024
https://doi.org/10.1371/journal.pone.0299028

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Osteoclasts
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Non-small cell lung cancer
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Apoptosis
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Lung and intrathoracic tumors
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Cell differentiation
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Metastasis
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Cancer treatment
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Small interfering RNA
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