Indisulam synergizes with melphalan to inhibit Multiple Myeloma malignancy via targeting TOP2A

• Chengyu Wu ,

  Contributed equally to this work with: Chengyu Wu, Chao Wu

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

  Affiliation Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  ⨯
• Chao Wu ,

  Contributed equally to this work with: Chengyu Wu, Chao Wu

  Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of General Practice, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  ⨯
• Jia Liu,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  ⨯
• Mingyuan Jia,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  ⨯
• Xinyi Zeng,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Hematology, Huadong Hospital Affiliated with Fudan University, Shanghai, China

  ⨯
• Ze Fu,

  Roles Methodology, Writing – review & editing

  Affiliation Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  ⨯
• Ziqi He,

  Roles Resources, Writing – review & editing

  Affiliation Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  ⨯
• Wenbin Xu ,

  Roles Project administration, Supervision, Writing – review & editing

  * E-mail: yanhua_candy@163.com (HY); francoisxu@126.com (WX)

  Affiliation Department of General Practice, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  ⨯
• Hua Yan

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: yanhua_candy@163.com (HY); francoisxu@126.com (WX)

  Affiliations Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Department of General Practice, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  https://orcid.org/0000-0001-5278-2444

  ⨯