Preclinical toxicity analyses of lentiviral vectors expressing the HIV-1 LTR-specific designer-recombinase Brec1

• Niklas Beschorner ,

  Contributed equally to this work with: Niklas Beschorner, Paul Künzle

  Roles Conceptualization, Data curation, Formal analysis, Investigation

  Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany, PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany

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• Paul Künzle ,

  Contributed equally to this work with: Niklas Beschorner, Paul Künzle

  Roles Conceptualization, Data curation, Formal analysis, Investigation

  Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany

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• Maike Voges,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany

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• Ilona Hauber,

  Roles Data curation, Investigation

  Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany

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• Daniela Indenbirken,

  Roles Formal analysis, Investigation

  Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany

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• Jacqueline Nakel,

  Roles Data curation, Investigation

  Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany

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• Sanamjeet Virdi,

  Roles Formal analysis

  Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany

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• Peter Bradtke,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Niels Christian Lory,

  Roles Data curation, Investigation

  Affiliation Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Michael Rothe,

  Roles Investigation

  Affiliation Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany

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• Maciej Paszkowski-Rogacz,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Medical Systems Biology, UCC, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany

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• Frank Buchholz,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources

  Affiliations PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany, Medical Systems Biology, UCC, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany

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• Adam Grundhoff,

  Roles Formal analysis, Methodology

  Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany

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• Axel Schambach,

  Roles Formal analysis, Resources

  Affiliation Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany

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• Christian Thirion,

  Roles Resources

  Affiliation SIRION Biotech GmbH, Gräfelfing, Germany

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• Hans-Willi Mittrücker,

  Roles Formal analysis, Methodology

  Affiliations Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Julian Schulze zur Wiesch,

  Roles Formal analysis, Methodology

  Affiliations German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany, Infectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Joachim Hauber,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Writing – original draft

  Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany, PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany

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•  [ ... ],
• Jan Chemnitz

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: jan.chemnitz@provirex.de

  Affiliations Leibniz-Institute of Virology (LIV), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg–Lübeck–Borstel–Riems, Germany, PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany

  https://orcid.org/0009-0001-7259-4974

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