Energy demanding RNA and protein metabolism drive dysfunctionality of HIV-specific T cell changes during chronic HIV infection

Lisa van Pul; Melissa Stunnenberg; Stefanie Kroeze; Karel A. van Dort; Brigitte D. M. Boeser-Nunnink; Agnes M. Harskamp; Teunis B. H. Geijtenbeek; Neeltje A. Kootstra

doi:10.1371/journal.pone.0298472

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Open Access

Peer-reviewed

Research Article

Energy demanding RNA and protein metabolism drive dysfunctionality of HIV-specific T cell changes during chronic HIV infection

Lisa van Pul,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands, Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands
⨯
Melissa Stunnenberg ,

Contributed equally to this work with: Melissa Stunnenberg, Stefanie Kroeze

Roles Formal analysis, Investigation, Methodology

Affiliations Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands
⨯
Stefanie Kroeze ,

Contributed equally to this work with: Melissa Stunnenberg, Stefanie Kroeze

Roles Formal analysis, Investigation, Writing – review & editing

Affiliations Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands, Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands
⨯
Karel A. van Dort,

Roles Formal analysis, Investigation

Affiliations Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands, Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands
⨯
Brigitte D. M. Boeser-Nunnink,

Roles Formal analysis, Investigation

Affiliations Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands, Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands
⨯
Agnes M. Harskamp,

Roles Resources

Affiliations Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands, Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands
⨯
Teunis B. H. Geijtenbeek,

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

Affiliations Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands
⨯
Neeltje A. Kootstra

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: n.a.kootstra@amsterdamumc.nl

Affiliations Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands, Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands

https://orcid.org/0000-0001-9429-7754

⨯

Energy demanding RNA and protein metabolism drive dysfunctionality of HIV-specific T cell changes during chronic HIV infection

Lisa van Pul,
Melissa Stunnenberg,
Stefanie Kroeze,
Karel A. van Dort,
Brigitte D. M. Boeser-Nunnink,
Agnes M. Harskamp,
Teunis B. H. Geijtenbeek,
Neeltje A. Kootstra

Published: October 2, 2024
https://doi.org/10.1371/journal.pone.0298472

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Cytotoxic T cells
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HIV infections
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HIV
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Gene expression
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Gene regulation
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Protein metabolism
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