Exposure of Helicobacter pylori to clarithromycin in vitro resulting in the development of resistance and triggers metabolic reprogramming associated with virulence and pathogenicity

• Naim Asyraf Rosli,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Medical Microbiology, Universiti Malaya, Kuala Lumpur, Malaysia

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• Anis Rageh Al-Maleki ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: anisrageh@um.edu.my, almaleki2004@gmail.com

  Affiliations Faculty of Medicine, Department of Medical Microbiology, Universiti Malaya, Kuala Lumpur, Malaysia, Faculty of Medicine and Health Sciences, Department of Medical Microbiology, Sana’a University, Sana’a, Yemen

  https://orcid.org/0000-0002-9927-8859

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• Mun Fai Loke,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Camtech Biomedical Pte Ltd, Singapore, Singapore

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• Sun Tee Tay,

  Roles Validation, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Medical Microbiology, Universiti Malaya, Kuala Lumpur, Malaysia

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• Mohd Salleh Rofiee,

  Roles Methodology

  Affiliation Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA, Selangor, Malaysia

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• Lay Kek Teh,

  Roles Methodology

  Affiliation Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA, Selangor, Malaysia

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• Mohd Zaki Salleh,

  Roles Methodology

  Affiliation Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA, Selangor, Malaysia

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• Jamuna Vadivelu

  Roles Validation, Writing – review & editing

  Affiliation Faculty of Medicine, Medical Education Research and Development Unit (MERDU), Universiti Malaya, Kuala Lumpur, Malaysia

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