Towards personalised anti-microbial and immune approaches to infections in acute care. Can real-time genomic-informed diagnosis of pathogens, and immune-focused therapies improve outcomes for patients? An observational, experimental study protocol

• Samuel Quarton ,

  Roles Conceptualization, Methodology, Writing – original draft

  * E-mail: s.quarton@bham.ac.uk

  Affiliations Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Institute of Inflammation & Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

  https://orcid.org/0009-0005-7235-3424

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• Kirsty McGee,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Institute of Inflammation & Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

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• Nicola Cumley,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Institute of Microbiology & Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

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• Mahboobeh Behruznia,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Institute of Microbiology & Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

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• Charlotte Jeff,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

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• Kylie Belchamber,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Institute of Inflammation & Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

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• Michael Cox,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Institute of Microbiology & Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

  https://orcid.org/0000-0002-4002-1506

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• David Thickett,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Institute of Inflammation & Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

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• Aaron Scott,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Institute of Inflammation & Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

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• Dhruv Parekh,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Institute of Inflammation & Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

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• Alan McNally ,

  Contributed equally to this work with: Alan McNally, Elizabeth Sapey

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Institute of Microbiology & Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

  https://orcid.org/0000-0002-3099-630X

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• Elizabeth Sapey

  Contributed equally to this work with: Alan McNally, Elizabeth Sapey

  Roles Conceptualization, Methodology, Writing – original draft

  Affiliations Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Director of PIONEER: Health Data Research UK (HDRUK) Health Data Research Hub for Acute Care, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, Patient Safety Research Collaborative, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

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