The polyglutamine domain is the primary driver of seeding in huntingtin aggregation

• Adam Skeens,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America

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• Chathuranga Siriwardhana,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America

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• Sophia E. Massinople,

  Roles Investigation, Writing – review & editing

  Affiliation The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America

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• Michelle M. Wunder,

  Roles Investigation, Writing – review & editing

  Affiliation The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America

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• Zachary L. Ellis,

  Roles Investigation

  Affiliation The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America

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• Kaitlyn M. Keith,

  Roles Investigation, Writing – review & editing

  Affiliation The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America

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• Tyler Girman,

  Roles Investigation, Writing – review & editing

  Affiliation The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America

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• Shelli L. Frey,

  Roles Investigation, Writing – review & editing

  Affiliation The Department of Chemistry, Gettysburg College, Gettysburg, Pennsylvania, United States of America

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• Justin Legleiter

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Software, Writing – original draft, Writing – review & editing

  * E-mail: justin.legleiter@mail.wvu.edu

  Affiliations The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America, Rockefeller Neurosciences Institutes, West Virginia University, Morgantown, West Virginia, United States of America, Department of Neuroscience, West Virginia University, Morgantown, West Virginia, United States of America

  https://orcid.org/0000-0002-5262-1867

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