Pharmacokinetics, pharmacodynamics, and toxicity of a PD-1-targeted IL-15 in cynomolgus monkeys

Changhua Ji; Bing Kuang; Bernard S. Buetow; Allison Vitsky; Yuanming Xu; Tzu-Hsuan Huang; Javier Chaparro-Riggers; Eugenia Kraynov; Diane Matsumoto

doi:10.1371/journal.pone.0298240

Loading metrics

Open Access

Peer-reviewed

Research Article

Pharmacokinetics, pharmacodynamics, and toxicity of a PD-1-targeted IL-15 in cynomolgus monkeys

Changhua Ji ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: changhua.ji2@pfizer.com

Affiliation Drug Safety Research and Development, Pfizer Inc, San Diego, California, United States of America

https://orcid.org/0000-0002-3329-6421

⨯
Bing Kuang,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Biomedical Design, Pfizer Inc, San Diego, California, United States of America
⨯
Bernard S. Buetow,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Drug Safety Research and Development, Pfizer Inc, San Diego, California, United States of America
⨯
Allison Vitsky,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Drug Safety Research and Development, Pfizer Inc, San Diego, California, United States of America
⨯
Yuanming Xu,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Cancer Immunology Discovery, Pfizer Inc, San Diego, California, United States of America
⨯
Tzu-Hsuan Huang,

Roles Investigation, Supervision, Writing – original draft, Writing – review & editing

Affiliation Cancer Immunology Discovery, Pfizer Inc, San Diego, California, United States of America
⨯
Javier Chaparro-Riggers,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Biomedical Design, Pfizer Inc, San Diego, California, United States of America
⨯
Eugenia Kraynov,

Roles Data curation, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Biomedical Design, Pfizer Inc, San Diego, California, United States of America
⨯
Diane Matsumoto

Roles Supervision, Writing – original draft, Writing – review & editing

Affiliation Drug Safety Research and Development, Pfizer Inc, San Diego, California, United States of America
⨯

Pharmacokinetics, pharmacodynamics, and toxicity of a PD-1-targeted IL-15 in cynomolgus monkeys

Changhua Ji,
Bing Kuang,
Bernard S. Buetow,
Allison Vitsky,
Yuanming Xu,
Tzu-Hsuan Huang,
Javier Chaparro-Riggers,
Eugenia Kraynov,
Diane Matsumoto

Published: February 5, 2024
https://doi.org/10.1371/journal.pone.0298240

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Monkeys
Is the Subject Area "Monkeys" applicable to this article?

Thanks for your feedback.
Euthanasia
Is the Subject Area "Euthanasia" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
NK cells
Is the Subject Area "NK cells" applicable to this article?

Thanks for your feedback.
Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
Toxicity
Is the Subject Area "Toxicity" applicable to this article?

Thanks for your feedback.
Lymphocytes
Is the Subject Area "Lymphocytes" applicable to this article?

Thanks for your feedback.
Platelets
Is the Subject Area "Platelets" applicable to this article?

Thanks for your feedback.