Structural insights into the modulation Of SOD1 aggregation By a fungal metabolite Phialomustin-B: Therapeutic potential in ALS

Sruthi Unni; Padmini Kommu; Snehal Aouti; Yedukondalu Nalli; M. M. Srinivas Bharath; Asif Ali; Balasundaram Padmanabhan

doi:10.1371/journal.pone.0298196

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Open Access

Peer-reviewed

Research Article

Structural insights into the modulation Of SOD1 aggregation By a fungal metabolite Phialomustin-B: Therapeutic potential in ALS

Sruthi Unni,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Biophysics, National Institute of Mental Health and Neurosciences, Bengaluru, India

https://orcid.org/0000-0001-9905-9464

⨯
Padmini Kommu,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Department of Biophysics, National Institute of Mental Health and Neurosciences, Bengaluru, India
⨯
Snehal Aouti,

Roles Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation Department of Biophysics, National Institute of Mental Health and Neurosciences, Bengaluru, India
⨯
Yedukondalu Nalli,

Roles Resources, Writing – review & editing

Affiliation CSIR-Indian Institute of Integrative Medicine, Natural Product Division, Jammu, India
⨯
M. M. Srinivas Bharath,

Roles Formal analysis, Investigation, Supervision, Writing – review & editing

Affiliation Department of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences, Bengaluru, India
⨯
Asif Ali,

Roles Resources, Writing – original draft, Writing – review & editing

Affiliations CSIR-Indian Institute of Integrative Medicine, Natural Product Division, Jammu, India, Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, India
⨯
Balasundaram Padmanabhan

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: balapaddy@gmail.com, paddy@nimhans.ac.in

Affiliation Department of Biophysics, National Institute of Mental Health and Neurosciences, Bengaluru, India

https://orcid.org/0000-0001-8434-828X

⨯

Structural insights into the modulation Of SOD1 aggregation By a fungal metabolite Phialomustin-B: Therapeutic potential in ALS

Sruthi Unni,
Padmini Kommu,
Snehal Aouti,
Yedukondalu Nalli,
M. M. Srinivas Bharath,
Asif Ali,
Balasundaram Padmanabhan

Published: March 6, 2024
https://doi.org/10.1371/journal.pone.0298196

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