The PINK1/Parkin pathway of mitophagy exerts a protective effect during prion disease

Anne Ward; Forrest Jessop; Robert Faris; Jason Hollister; Daniel Shoup; Brent Race; Catharine M. Bosio; Suzette A. Priola

doi:10.1371/journal.pone.0298095

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Open Access

Peer-reviewed

Research Article

The PINK1/Parkin pathway of mitophagy exerts a protective effect during prion disease

Anne Ward,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana
⨯
Forrest Jessop,

Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Writing – review & editing

Affiliation Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana
⨯
Robert Faris,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Jason Hollister,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana
⨯
Daniel Shoup,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana
⨯
Brent Race,

Roles Methodology, Resources, Writing – review & editing

Affiliation Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana
⨯
Catharine M. Bosio,

Roles Methodology, Resources, Supervision, Writing – review & editing

Affiliation Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana
⨯
Suzette A. Priola

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: spriola@nih.gov

Affiliation Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana

https://orcid.org/0000-0003-0303-3951

⨯

The PINK1/Parkin pathway of mitophagy exerts a protective effect during prion disease

Anne Ward,
Forrest Jessop,
Robert Faris,
Jason Hollister,
Daniel Shoup,
Brent Race,
Catharine M. Bosio,
Suzette A. Priola

Published: February 23, 2024
https://doi.org/10.1371/journal.pone.0298095

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Mitochondria
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Prion diseases
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Respiratory infections
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Animal prion diseases
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Genetically modified animals
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Mouse models
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Protein expression
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Parkinson disease
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