Pilot RCT comparing low-dose naltrexone, gabapentin and placebo to reduce pain among people with HIV with alcohol problems

Judith I. Tsui; Sarah L. Rossi; Debbie M. Cheng; Sally Bendiks; Marina Vetrova; Elena Blokhina; Michael Winter; Natalia Gnatienko; Miroslav Backonja; Kendall Bryant; Evgeny Krupitsky; Jeffrey H. Samet

doi:10.1371/journal.pone.0297948

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Open Access

Peer-reviewed

Research Article

Pilot RCT comparing low-dose naltrexone, gabapentin and placebo to reduce pain among people with HIV with alcohol problems

Judith I. Tsui ,

Contributed equally to this work with: Judith I. Tsui, Sarah L. Rossi, Debbie M. Cheng, Sally Bendiks, Marina Vetrova, Elena Blokhina, Michael Winter, Natalia Gnatienko, Miroslav Backonja, Kendall Bryant, Evgeny Krupitsky, Jeffrey H. Samet

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

* E-mail: tsuij@uw.edu

Affiliation Department of Medicine, Division of General Internal Medicine University of Washington School of Medicine/Harborview Medical Center, Seattle, Washington, United States of America

https://orcid.org/0000-0003-0877-5399

⨯
Sarah L. Rossi ,

Contributed equally to this work with: Judith I. Tsui, Sarah L. Rossi, Debbie M. Cheng, Sally Bendiks, Marina Vetrova, Elena Blokhina, Michael Winter, Natalia Gnatienko, Miroslav Backonja, Kendall Bryant, Evgeny Krupitsky, Jeffrey H. Samet

Roles Investigation, Project administration, Visualization, Writing – original draft

Affiliation Department of Medicine, Section of General Internal Medicine, Boston Medical Center, Clinical Addiction Research and Education (CARE) Unit, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-4168-5267

⨯
Debbie M. Cheng ,

Contributed equally to this work with: Judith I. Tsui, Sarah L. Rossi, Debbie M. Cheng, Sally Bendiks, Marina Vetrova, Elena Blokhina, Michael Winter, Natalia Gnatienko, Miroslav Backonja, Kendall Bryant, Evgeny Krupitsky, Jeffrey H. Samet

Roles Formal analysis, Methodology, Validation, Writing – review & editing

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, Unites States of America
⨯
Sally Bendiks ,

Contributed equally to this work with: Judith I. Tsui, Sarah L. Rossi, Debbie M. Cheng, Sally Bendiks, Marina Vetrova, Elena Blokhina, Michael Winter, Natalia Gnatienko, Miroslav Backonja, Kendall Bryant, Evgeny Krupitsky, Jeffrey H. Samet

Roles Investigation, Project administration, Writing – review & editing

Affiliation Department of Medicine, Section of General Internal Medicine, Boston Medical Center, Clinical Addiction Research and Education (CARE) Unit, Boston, Massachusetts, United States of America
⨯
Marina Vetrova ,

Contributed equally to this work with: Judith I. Tsui, Sarah L. Rossi, Debbie M. Cheng, Sally Bendiks, Marina Vetrova, Elena Blokhina, Michael Winter, Natalia Gnatienko, Miroslav Backonja, Kendall Bryant, Evgeny Krupitsky, Jeffrey H. Samet

Roles Investigation, Writing – review & editing

Affiliation Pavlov University, St. Petersburg, Russian Federation
⨯
Elena Blokhina ,

Contributed equally to this work with: Judith I. Tsui, Sarah L. Rossi, Debbie M. Cheng, Sally Bendiks, Marina Vetrova, Elena Blokhina, Michael Winter, Natalia Gnatienko, Miroslav Backonja, Kendall Bryant, Evgeny Krupitsky, Jeffrey H. Samet

Roles Investigation, Project administration, Writing – review & editing

Affiliation Pavlov University, St. Petersburg, Russian Federation
⨯
Michael Winter ,

Contributed equally to this work with: Judith I. Tsui, Sarah L. Rossi, Debbie M. Cheng, Sally Bendiks, Marina Vetrova, Elena Blokhina, Michael Winter, Natalia Gnatienko, Miroslav Backonja, Kendall Bryant, Evgeny Krupitsky, Jeffrey H. Samet

Roles Data curation, Formal analysis, Software, Visualization, Writing – review & editing

Affiliation Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, Massachusetts, United States of America
⨯
Natalia Gnatienko ,

Contributed equally to this work with: Judith I. Tsui, Sarah L. Rossi, Debbie M. Cheng, Sally Bendiks, Marina Vetrova, Elena Blokhina, Michael Winter, Natalia Gnatienko, Miroslav Backonja, Kendall Bryant, Evgeny Krupitsky, Jeffrey H. Samet

Roles Investigation, Project administration, Writing – review & editing

Affiliation Department of Medicine, Section of General Internal Medicine, Boston Medical Center, Clinical Addiction Research and Education (CARE) Unit, Boston, Massachusetts, United States of America
⨯
Miroslav Backonja ,

Contributed equally to this work with: Judith I. Tsui, Sarah L. Rossi, Debbie M. Cheng, Sally Bendiks, Marina Vetrova, Elena Blokhina, Michael Winter, Natalia Gnatienko, Miroslav Backonja, Kendall Bryant, Evgeny Krupitsky, Jeffrey H. Samet

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Kendall Bryant ,

Contributed equally to this work with: Judith I. Tsui, Sarah L. Rossi, Debbie M. Cheng, Sally Bendiks, Marina Vetrova, Elena Blokhina, Michael Winter, Natalia Gnatienko, Miroslav Backonja, Kendall Bryant, Evgeny Krupitsky, Jeffrey H. Samet

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation HIV/AIDS Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Evgeny Krupitsky ,

Contributed equally to this work with: Judith I. Tsui, Sarah L. Rossi, Debbie M. Cheng, Sally Bendiks, Marina Vetrova, Elena Blokhina, Michael Winter, Natalia Gnatienko, Miroslav Backonja, Kendall Bryant, Evgeny Krupitsky, Jeffrey H. Samet

Roles Investigation, Project administration, Supervision, Writing – review & editing

Affiliations Pavlov University, St. Petersburg, Russian Federation, Department of Addictions, V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Petersburg, Russian Federation

https://orcid.org/0000-0002-0529-4525

⨯
Jeffrey H. Samet

Contributed equally to this work with: Judith I. Tsui, Sarah L. Rossi, Debbie M. Cheng, Sally Bendiks, Marina Vetrova, Elena Blokhina, Michael Winter, Natalia Gnatienko, Miroslav Backonja, Kendall Bryant, Evgeny Krupitsky, Jeffrey H. Samet

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliations Department of Medicine, Section of General Internal Medicine, Boston University School of Medicine/Boston Medical Center, Clinical Addiction Research and Education (CARE) Unit, Boston, Massachusetts, United States of America, Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts, United States of America
⨯

Pilot RCT comparing low-dose naltrexone, gabapentin and placebo to reduce pain among people with HIV with alcohol problems

Judith I. Tsui,
Sarah L. Rossi,
Debbie M. Cheng,
Sally Bendiks,
Marina Vetrova,
Elena Blokhina,
Michael Winter,
Natalia Gnatienko,
Miroslav Backonja,
Kendall Bryant

Published: February 26, 2024
https://doi.org/10.1371/journal.pone.0297948

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