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pH-responsive targeted nanoparticles release ERK-inhibitor in the hypoxic zone and sensitize free gemcitabine in mutant K-Ras-addicted pancreatic cancer cells and mouse model
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Debasmita Dutta,
Roles Formal analysis, Investigation, Methodology, Writing – original draft
Current address: Dept. of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
Affiliation Department of Coatings and Polymeric Materials, North Dakota State University, Fargo, ND, United States of America
⨯ - Priyanka Ray,
- Archana De,
- Arnab Ghosh,
- Raj Shankar Hazra,
- Pratyusha Ghosh,
- Snigdha Banerjee ,
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Francisco J. Diaz,
Roles Software, Validation
Affiliation Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, United States of America
⨯ - Sunil P. Upadhyay,
- Mohiuddin Quadir ,
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Sushanta K. Banerjee
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing
* E-mail: Snigdha.banerjee@va.gov (SB); sbanerjee2@kumc.edu, cancerresearchunit@icloud.com (SKB); Mohiuddin.quadir@ndsu.edu (MQ)
Affiliations Cancer Research Unit, VA Medical Center, Kansas City, MO, United States of America, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, United States of America
⨯
https://orcid.org/0000-0003-0235-4649
pH-responsive targeted nanoparticles release ERK-inhibitor in the hypoxic zone and sensitize free gemcitabine in mutant K-Ras-addicted pancreatic cancer cells and mouse model
- Debasmita Dutta,
- Priyanka Ray,
- Archana De,
- Arnab Ghosh,
- Raj Shankar Hazra,
- Pratyusha Ghosh,
- Snigdha Banerjee,
- Francisco J. Diaz,
- Sunil P. Upadhyay,
- Mohiuddin Quadir
- Published: April 30, 2024
- https://doi.org/10.1371/journal.pone.0297749