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Open Access

Peer-reviewed

Research Article

Antibiotics affect the pharmacokinetics of n-butylphthalide in vivo by altering the intestinal microbiota

Xiangchen Li,

Roles Formal analysis

Affiliation Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
⨯
Xiaoli Guo,

Roles Formal analysis

Affiliation Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
⨯
Yixin Liu,

Roles Data curation

Affiliation Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
⨯
Feifei Ren,

Roles Investigation

Affiliation Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
⨯
Shan Li,

Roles Investigation

Affiliation Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
⨯
Xiuling Yang,

Roles Writing – original draft

Affiliation Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
⨯
Jian Liu ,

Roles Formal analysis

* E-mail: ljhaiyang@aliyun.com (JL); 777yyy@sina.cn (ZZ)

Affiliation Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
⨯
Zhiqing Zhang

Roles Writing – review & editing

* E-mail: ljhaiyang@aliyun.com (JL); 777yyy@sina.cn (ZZ)

Affiliation Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China

https://orcid.org/0000-0002-9306-3267

⨯

Antibiotics affect the pharmacokinetics of n-butylphthalide in vivo by altering the intestinal microbiota

Xiangchen Li,
Xiaoli Guo,
Yixin Liu,
Feifei Ren,
Shan Li,
Xiuling Yang,
Jian Liu,
Zhiqing Zhang

x

Published: June 25, 2024
https://doi.org/10.1371/journal.pone.0297713

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Gastrointestinal tract
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Gut bacteria
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Antibiotics
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Probiotics
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Pharmacokinetics
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Drug metabolism
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Enzyme metabolism
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Metabolic pathways
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