Perinatal choline supplementation prevents learning and memory deficits and reduces brain amyloid Aβ42 deposition in AppNL-G-F Alzheimer’s disease model mice

Thomas A. Bellio; Jessenia Y. Laguna-Torres; Mary S. Campion; Jay Chou; Sheila Yee; Jan K. Blusztajn; Tiffany J. Mellott

doi:10.1371/journal.pone.0297289

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Open Access

Peer-reviewed

Research Article

Perinatal choline supplementation prevents learning and memory deficits and reduces brain amyloid Aβ42 deposition in App^NL-G-F Alzheimer’s disease model mice

Thomas A. Bellio ,

Roles Data curation, Formal analysis, Investigation, Software, Visualization, Writing – original draft, Writing – review & editing

* E-mail: tbellio@bu.edu (TAB); tmellott@bu.edu (TJM)

Affiliation Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America

https://orcid.org/0009-0007-7807-6848

⨯
Jessenia Y. Laguna-Torres,

Roles Data curation, Investigation, Project administration

Affiliation Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America
⨯
Mary S. Campion,

Roles Data curation, Investigation, Methodology, Validation

Affiliation Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America
⨯
Jay Chou,

Roles Data curation, Investigation

Affiliation Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America
⨯
Sheila Yee,

Roles Data curation, Investigation

Affiliation Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-5221-5957

⨯
Jan K. Blusztajn,

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America
⨯
Tiffany J. Mellott

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: tbellio@bu.edu (TAB); tmellott@bu.edu (TJM)

Affiliation Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America

https://orcid.org/0000-0003-3287-9374

⨯

Perinatal choline supplementation prevents learning and memory deficits and reduces brain amyloid Aβ42 deposition in App^NL-G-F Alzheimer’s disease model mice

Thomas A. Bellio,
Jessenia Y. Laguna-Torres,
Mary S. Campion,
Jay Chou,
Sheila Yee,
Jan K. Blusztajn,
Tiffany J. Mellott

Published: February 5, 2024
https://doi.org/10.1371/journal.pone.0297289

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