Factors predicting mortality in hospitalised HIV-negative children with lower-chest-wall indrawing pneumonia and implications for management

Katherine E. Gallagher; Juliet O. Awori; Maria D. Knoll; Julia Rhodes; Melissa M. Higdon; Laura L. Hammitt; Christine Prosperi; Henry C. Baggett; W. Abdullah Brooks; Nicholas Fancourt; Daniel R. Feikin; Stephen R. C. Howie; Karen L. Kotloff; Milagritos D. Tapia; Orin S. Levine; Shabir A. Madhi; David R. Murdoch; Katherine L. O’Brien; Donald M. Thea; Vicky L. Baillie; Bernard E. Ebruke; Alice Kamau; David P. Moore; Lawrence Mwananyanda; Emmanuel O. Olutunde; Phil Seidenberg; Samba O. Sow; Somsak Thamthitiwat; J. Anthony G. Scott; for The PERCH Study Group

doi:10.1371/journal.pone.0297159

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Open Access

Peer-reviewed

Research Article

Factors predicting mortality in hospitalised HIV-negative children with lower-chest-wall indrawing pneumonia and implications for management

Katherine E. Gallagher ,

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

* E-mail: Katherine.Gallagher@lshtm.ac.uk

Affiliations Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom, Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya

https://orcid.org/0000-0002-5604-7647

⨯
Juliet O. Awori,

Roles Data curation, Project administration, Writing – review & editing

Affiliation Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya

https://orcid.org/0000-0002-3698-4721

⨯
Maria D. Knoll,

Roles Supervision, Writing – review & editing

Affiliation Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

https://orcid.org/0000-0001-9041-2671

⨯
Julia Rhodes,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Global Disease Detection Center, Thailand Ministry of Public Health–US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand
⨯
Melissa M. Higdon,

Roles Data curation, Writing – review & editing

Affiliation Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Laura L. Hammitt,

Roles Data curation, Supervision, Writing – review & editing

Affiliations Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya
⨯
Christine Prosperi,

Roles Data curation, Writing – review & editing

Affiliation Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Henry C. Baggett,

Roles Supervision, Writing – review & editing

Affiliations Global Disease Detection Center, Thailand Ministry of Public Health–US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand, Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
W. Abdullah Brooks,

Roles Supervision, Writing – review & editing

Affiliations Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka and Matlab, Bangladesh

https://orcid.org/0000-0001-9871-5546

⨯
Nicholas Fancourt,

Roles Data curation, Writing – review & editing

Affiliation Menzies School of Health Research, Charles Darwin University, Darwin, Australia
⨯
Daniel R. Feikin,

Roles Supervision, Writing – review & editing

Affiliations Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Division of Viral Diseases, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Stephen R. C. Howie,

Roles Supervision, Writing – review & editing

Affiliations Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Basse, The Gambia, Department of Paediatrics, University of Auckland, Auckland, New Zealand
⨯
Karen L. Kotloff,

Roles Supervision, Writing – review & editing

Affiliation Department of Pediatrics, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Milagritos D. Tapia,

Roles Supervision, Writing – review & editing

Affiliation Department of Pediatrics, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Orin S. Levine,

Roles Supervision, Writing – review & editing

Current address: Bill & Melinda Gates Foundation, Seattle, Washington, United States of America

Affiliation Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Shabir A. Madhi,

Roles Supervision, Writing – review & editing

Affiliations South African Medical Research Council: Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa, Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa
⨯
David R. Murdoch,

Roles Supervision, Writing – review & editing

Affiliations Department of Pathology and Biomedical Sciences, University of Otago, Christchurch, New Zealand, Microbiology Unit, Canterbury Health Laboratories, Christchurch, New Zealand

https://orcid.org/0000-0003-0070-8001

⨯
Katherine L. O’Brien,

Roles Supervision, Writing – review & editing

Affiliation Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Donald M. Thea,

Roles Supervision, Writing – review & editing

Affiliation Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, United States of America
⨯
Vicky L. Baillie,

Roles Data curation, Writing – review & editing

Affiliations South African Medical Research Council: Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa, Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa

https://orcid.org/0000-0003-1327-9090

⨯
Bernard E. Ebruke,

Roles Data curation, Supervision, Writing – review & editing

Affiliation Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Basse, The Gambia
⨯
Alice Kamau,

Roles Data curation, Writing – review & editing

Affiliation Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya
⨯
David P. Moore,

Roles Supervision, Writing – review & editing

Affiliations South African Medical Research Council: Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa, Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa, Department of Paediatrics & Child Health, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa
⨯
Lawrence Mwananyanda,

Roles Supervision, Writing – review & editing

Affiliations Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, United States of America, Right to Care-Zambia, Lusaka, Zambia

https://orcid.org/0000-0002-3034-749X

⨯
Emmanuel O. Olutunde,

Roles Data curation, Writing – review & editing

Affiliation Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Basse, The Gambia
⨯
Phil Seidenberg,

Roles Supervision, Writing – review & editing

Current address: Department of Emergency Medicine, University of New Mexico, Albuquerque, New Mexico, United States of America

Affiliation Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, United States of America
⨯
Samba O. Sow,

Roles Supervision, Writing – review & editing

Affiliation Centre pour le Développement des Vaccins (CVD-Mali), Bamako, Mali
⨯
Somsak Thamthitiwat,

Roles Supervision, Writing – review & editing

Affiliation Global Disease Detection Center, Thailand Ministry of Public Health–US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand
⨯
J. Anthony G. Scott,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom, Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya

https://orcid.org/0000-0001-7533-5006

⨯
[ ... ],
for The PERCH Study Group

¶Membership of The PERCH Study Group is listed in the Acknowledgments.
⨯
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Factors predicting mortality in hospitalised HIV-negative children with lower-chest-wall indrawing pneumonia and implications for management

Katherine E. Gallagher,
Juliet O. Awori,
Maria D. Knoll,
Julia Rhodes,
Melissa M. Higdon,
Laura L. Hammitt,
Christine Prosperi,
Henry C. Baggett,
W. Abdullah Brooks,
Nicholas Fancourt

Published: March 11, 2024
https://doi.org/10.1371/journal.pone.0297159

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