Naldemedine is associated with earlier defecation in critically ill patients with opioid-induced constipation: A retrospective, single-center cohort study

• Seiya Nishiyama ,

  Contributed equally to this work with: Seiya Nishiyama, Shigehiko Uchino, Yusuke Sasabuchi

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, Saitama Medical Center, Omiya, Saitama, Japan

  ⨯
• Shigehiko Uchino ,

  Contributed equally to this work with: Seiya Nishiyama, Shigehiko Uchino, Yusuke Sasabuchi

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, Saitama Medical Center, Omiya, Saitama, Japan

  ⨯
• Yusuke Sasabuchi ,

  Contributed equally to this work with: Seiya Nishiyama, Shigehiko Uchino, Yusuke Sasabuchi

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Data Science Center, Jichi Medical University, Shimotsuke, Tochigi, Japan

  ⨯
• Tomoyuki Masuyama ,

  Roles Methodology, Writing – review & editing

  * E-mail: tomomasuyama@jichi.ac.jp

  ¶‡ TM, AKL and MS also contributed equally to this work.

  Affiliation Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, Saitama Medical Center, Omiya, Saitama, Japan

  https://orcid.org/0000-0003-2148-5556

  ⨯
• Alan Kawarai Lefor ,

  Roles Methodology, Writing – review & editing

  ¶‡ TM, AKL and MS also contributed equally to this work.

  Affiliation Department of Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan

  https://orcid.org/0000-0001-6673-5630

  ⨯
• Masamitsu Sanui

  Roles Methodology, Writing – review & editing

  ¶‡ TM, AKL and MS also contributed equally to this work.

  Affiliation Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, Saitama Medical Center, Omiya, Saitama, Japan

  https://orcid.org/0000-0002-0184-0381

  ⨯