Deciphering the immune landscape of head and neck squamous cell carcinoma: A single-cell transcriptomic analysis of regulatory T cell responses to PD-1 blockade therapy

• Adib Miraki Feriz ,

  Contributed equally to this work with: Adib Miraki Feriz, Fatemeh Bahraini

  Roles Conceptualization, Formal analysis, Methodology, Software, Validation, Writing – original draft

  Affiliation Student Research Committee, Birjand University of Medical Sciences (BUMS), Birjand, Iran

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• Fatemeh Bahraini ,

  Contributed equally to this work with: Adib Miraki Feriz, Fatemeh Bahraini

  Roles Conceptualization, Formal analysis, Writing – original draft

  Affiliation Student Research Committee, Birjand University of Medical Sciences (BUMS), Birjand, Iran

  https://orcid.org/0000-0003-0428-6379

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• Arezou Khosrojerdi,

  Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Infectious Diseases Research Center, BUMS, Birjand, Iran

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• Setareh Azarkar,

  Roles Conceptualization, Investigation, Visualization, Writing – original draft

  Affiliation Student Research Committee, Birjand University of Medical Sciences (BUMS), Birjand, Iran

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• Seyed Mehdi Sajjadi,

  Roles Data curation, Writing – original draft, Writing – review & editing

  Affiliation Cellular and Molecular Research Center (CMRC), BUMS, Birjand, Iran

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• Edris HosseiniGol,

  Roles Data curation, Software

  Affiliation Department of Computer Engineering, University of Birjand, Birjand, Iran

  https://orcid.org/0000-0002-6279-6206

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• Mohammad Amin Honardoost,

  Roles Investigation, Visualization

  Affiliation Laboratory of Systems Biology and Data Analytics, Genome Institute of Singapore, A*STAR, Singapore, Singapore

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• Samira Saghafi,

  Roles Investigation, Writing – review & editing

  Affiliations Cellular and Molecular Research Center (CMRC), BUMS, Birjand, Iran, Department of Internal Medicine, School of Medicine, BUMS, Birjand, Iran

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• Nicola Silvestris,

  Roles Visualization, Writing – review & editing

  Affiliation Medical Oncology Unit, Department of Human Pathology “G. Barresi”, University of Messina, Messina, Italy

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• Patrizia Leone,

  Roles Writing – original draft

  Affiliation Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy

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• Hossein Safarpour ,

  Roles Project administration, Supervision, Validation

  * E-mail: safarpour701@yahoo.com (HS); vito.racanelli@unitn.it (VR)

  Affiliation Cellular and Molecular Research Center (CMRC), BUMS, Birjand, Iran

  https://orcid.org/0000-0001-9883-9186

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• Vito Racanelli

  Roles Project administration, Supervision

  * E-mail: safarpour701@yahoo.com (HS); vito.racanelli@unitn.it (VR)

  Affiliation Centre for Medical Sciences (CISMed), University of Trento and Internal Medicine Division, Santa Chiara Hospital, Provincial Health Care Agency (APSS), Trento, Italy

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