Poly-(ADP-ribose) polymerases inhibition by olaparib attenuates activities of the NLRP3 inflammasome and of NF-κB in THP-1 monocytes

• Khamis Mustafa ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  ¶‡ KM and YH are co-first authors. HL and PQ are joint senior authors to this work.

  Affiliation Institute of Heart and Vessel Diseases, The Second Affiliated Hospital, Dalian Medical University, Dalian, China

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• Ying Han ,

  Roles Formal analysis, Methodology, Visualization

  ¶‡ KM and YH are co-first authors. HL and PQ are joint senior authors to this work.

  Affiliation Department of Cardiology, Jinqiu Hospital of Liaoning Province, Shenyang, China

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• Dan He,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Institute of Heart and Vessel Diseases, The Second Affiliated Hospital, Dalian Medical University, Dalian, China

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• Ying Wang,

  Roles Data curation, Investigation, Methodology, Validation

  Affiliation Institute of Heart and Vessel Diseases, The Second Affiliated Hospital, Dalian Medical University, Dalian, China

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• Nan Niu,

  Roles Formal analysis, Visualization

  Affiliation Department of Cardiology, The Second Affiliated Hospital, Dalian Medical University, Dalian, China

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• Pedro A. Jose,

  Roles Formal analysis, Visualization, Writing – review & editing

  Affiliations Department of Medicine, The George Washington University School of Medicine & Health Sciences, Washington, District of Columbia, United States of America, Department of Physiology/Pharmacology, The George Washington University School of Medicine & Health Sciences, Washington, District of Columbia, United States of America

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• Yinong Jiang,

  Roles Formal analysis, Visualization

  Affiliation Department of Cardiology, The First Affiliated Hospital, Dalian Medical University, Dalian, China

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• Jeffrey B. Kopp,

  Roles Formal analysis, Validation, Writing – review & editing

  Affiliation Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Hewang Lee ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: lih@gwu.edu (HL); qupeng777@aliyun.com (PQ)

  ¶‡ KM and YH are co-first authors. HL and PQ are joint senior authors to this work.

  Affiliations Institute of Heart and Vessel Diseases, The Second Affiliated Hospital, Dalian Medical University, Dalian, China, Department of Medicine, The George Washington University School of Medicine & Health Sciences, Washington, District of Columbia, United States of America, Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0003-1338-2573

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• Peng Qu

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation

  * E-mail: lih@gwu.edu (HL); qupeng777@aliyun.com (PQ)

  ¶‡ KM and YH are co-first authors. HL and PQ are joint senior authors to this work.

  Affiliations Institute of Heart and Vessel Diseases, The Second Affiliated Hospital, Dalian Medical University, Dalian, China, Department of Cardiology, The Second Affiliated Hospital, Dalian Medical University, Dalian, China, Faculty of Medicine, Dalian University of Technology, Dalian, China

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