Human alveolar macrophages display marked hypo-responsiveness to IFN-γ in both proteomic and gene expression analysis

• Bonnie A. Thiel ,

  Roles Formal analysis, Writing – original draft, Writing – review & editing

  * E-mail: bonnie.thiel@case.edu

  Affiliation Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0003-3386-5580

  ⨯
• Kathleen C. Lundberg,

  Roles Data curation

  Affiliation Department of Nutrition, Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

  ⨯
• Daniela Schlatzer,

  Roles Data curation

  Affiliation Department of Nutrition, Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

  ⨯
• Jessica Jarvela,

  Roles Data curation

  Affiliation Division of Pulmonary, Critical Care, and Sleep Medicine, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, United States of America

  ⨯
• Qing Li,

  Roles Data curation

  Affiliation Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States of America

  ⨯
• Rachel Shaw,

  Roles Data curation

  Affiliation Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States of America

  ⨯
• Scott M. Reba,

  Roles Data curation, Writing – original draft

  Affiliation Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States of America

  ⨯
• Shane Fletcher,

  Roles Data curation, Writing – original draft

  Affiliation Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States of America

  ⨯
• Sara E. Beckloff,

  Roles Data curation, Methodology

  Affiliation Biobot Analytics, Cambridge, Massachusetts, United States of America

  ⨯
• Mark R. Chance,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Department of Nutrition, Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

  ⨯
• W. Henry Boom,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States of America

  ⨯
• Richard F. Silver ,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  ¶‡ RFS and GB share senior authorship on this work.

  Affiliations Division of Pulmonary, Critical Care, and Sleep Medicine, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, United States of America, Division of Pulmonary, Critical Care, and Sleep Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

  ⨯
• Gurkan Bebek

  Roles Formal analysis, Methodology, Supervision, Writing – review & editing

  ¶‡ RFS and GB share senior authorship on this work.

  Affiliation Department of Nutrition, Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0003-3081-3371

  ⨯