Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression

• Shota Moriya ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: moriya@tokyo-med.ac.jp (SM); miyazawa@tokyo-med.ac.jp (KM)

  Affiliation Department of Biochemistry, Tokyo Medical University, Tokyo, Japan

  https://orcid.org/0000-0002-9921-2622

  ⨯
• Hiromi Kazama,

  Roles Formal analysis, Investigation

  Affiliation Department of Biochemistry, Tokyo Medical University, Tokyo, Japan

  ⨯
• Hirotsugu Hino,

  Roles Investigation

  Affiliations Department of Biochemistry, Tokyo Medical University, Tokyo, Japan, Division of Anatomical Science, Department of Functional Morphology, Nihon University School of Medicine, Tokyo, Japan

  ⨯
• Naoharu Takano,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry, Tokyo Medical University, Tokyo, Japan

  ⨯
• Masaki Hiramoto,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry, Tokyo Medical University, Tokyo, Japan

  ⨯
• Shin Aizawa,

  Roles Resources

  Affiliation Division of Anatomical Science, Department of Functional Morphology, Nihon University School of Medicine, Tokyo, Japan

  ⨯
• Keisuke Miyazawa

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: moriya@tokyo-med.ac.jp (SM); miyazawa@tokyo-med.ac.jp (KM)

  Affiliation Department of Biochemistry, Tokyo Medical University, Tokyo, Japan

  ⨯