Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells

• Chao Li ,

  Contributed equally to this work with: Chao Li, Zhong Liu

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Zhong Liu ,

  Contributed equally to this work with: Chao Li, Zhong Liu

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Justin Anderson,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliations Department of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James Cystic Fibrosis Research Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

  https://orcid.org/0000-0002-8894-3876

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• Zhongyu Liu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Gregory Fleming James Cystic Fibrosis Research Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Liping Tang,

  Roles Data curation, Formal analysis, Methodology

  Affiliations Gregory Fleming James Cystic Fibrosis Research Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Yao Li,

  Roles Data curation, Formal analysis, Methodology

  Affiliations Gregory Fleming James Cystic Fibrosis Research Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

  https://orcid.org/0000-0002-7785-5563

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• Ning Peng,

  Roles Data curation, Formal analysis, Methodology

  Affiliations Gregory Fleming James Cystic Fibrosis Research Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Jianguo Chen,

  Roles Data curation, Formal analysis, Methodology

  Affiliations Gregory Fleming James Cystic Fibrosis Research Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Xueming Liu,

  Roles Formal analysis, Methodology

  Affiliation Key Laboratory of Imaging Processing and Intelligent Control, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, Hubei, China

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• Lianwu Fu,

  Roles Formal analysis, Methodology

  Affiliations Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James Cystic Fibrosis Research Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Tim M. Townes,

  Roles Methodology

  Affiliation Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Steven M. Rowe,

  Roles Conceptualization, Methodology

  Affiliations Gregory Fleming James Cystic Fibrosis Research Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• David M. Bedwell,

  Roles Conceptualization, Methodology, Visualization

  Affiliations Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James Cystic Fibrosis Research Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Jennifer Guimbellot,

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Visualization

  Affiliations Department of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James Cystic Fibrosis Research Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Rui Zhao

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: ruizhao@uab.edu

  Affiliations Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James Cystic Fibrosis Research Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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