Vitamin K2 (MK-7) attenuates LPS-induced acute lung injury via inhibiting inflammation, apoptosis, and ferroptosis

Yulian Wang; Weidong Yang; Lulu Liu; Lihong Liu; Jiepeng Chen; Lili Duan; Yuyuan Li; Shuzhuang Li

doi:10.1371/journal.pone.0294763

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Open Access

Peer-reviewed

Research Article

Vitamin K2 (MK-7) attenuates LPS-induced acute lung injury via inhibiting inflammation, apoptosis, and ferroptosis

Yulian Wang ,

Contributed equally to this work with: Yulian Wang, Weidong Yang

Roles Data curation, Investigation, Project administration, Validation

Affiliation College of Basic Medical Science, Dalian Medical University, Dalian, China
⨯
Weidong Yang ,

Contributed equally to this work with: Yulian Wang, Weidong Yang

Roles Data curation, Investigation, Project administration, Validation

Affiliation College of Basic Medical Science, Dalian Medical University, Dalian, China
⨯
Lulu Liu,

Roles Data curation, Project administration, Validation

Affiliation College of Basic Medical Science, Dalian Medical University, Dalian, China
⨯
Lihong Liu,

Roles Conceptualization, Software, Supervision, Writing – review & editing

Affiliation College of Basic Medical Science, Dalian Medical University, Dalian, China
⨯
Jiepeng Chen,

Roles Conceptualization, Investigation, Software

Affiliation Sungen Bioscience Co., Ltd., Guangdong, China
⨯
Lili Duan,

Roles Conceptualization, Investigation, Software

Affiliation Sungen Bioscience Co., Ltd., Guangdong, China
⨯
Yuyuan Li ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – original draft

* E-mail: shuzhuangli@126.com (SL); liyuyuan831221@163.com (YL)

Affiliation Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China

https://orcid.org/0000-0002-4570-7478

⨯
Shuzhuang Li

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – review & editing

* E-mail: shuzhuangli@126.com (SL); liyuyuan831221@163.com (YL)

Affiliation College of Basic Medical Science, Dalian Medical University, Dalian, China
⨯

Vitamin K2 (MK-7) attenuates LPS-induced acute lung injury via inhibiting inflammation, apoptosis, and ferroptosis

Yulian Wang,
Weidong Yang,
Lulu Liu,
Lihong Liu,
Jiepeng Chen,
Lili Duan,
Yuyuan Li,
Shuzhuang Li

Published: November 27, 2023
https://doi.org/10.1371/journal.pone.0294763

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Apoptosis
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Inflammation
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MAPK signaling cascades
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Cytokines
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Elastin
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Protein expression
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Vitamin K
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Lipid peroxidation
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