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Open Access

Peer-reviewed

Research Article

Cathepsin B aggravates atherosclerosis in ApoE-deficient mice by modulating vascular smooth muscle cell pyroptosis through NF-κB / NLRP3 signaling pathway

Hui Li,

Roles Methodology, Software, Validation, Writing – original draft

Affiliations Department of Cardiology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Institute of Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China, School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China
⨯
Quanwei Zhao,

Roles Data curation, Formal analysis, Visualization

Affiliations Department of Cardiology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Institute of Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China, School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China
⨯
Danan Liu ,

Roles Funding acquisition, Investigation, Project administration, Writing – review & editing

* E-mail: liudanan2000@163.com

Affiliations Department of Cardiology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Institute of Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China

https://orcid.org/0009-0004-8852-1624

⨯
Bo Zhou,

Roles Formal analysis, Software

Affiliations Department of Cardiology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Institute of Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China, School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China
⨯
Fujun Liao,

Roles Data curation, Formal analysis

Affiliations Department of Cardiology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Institute of Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China, School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China
⨯
Long Chen

Roles Data curation

Affiliations Department of Cardiology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China, Institute of Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China, School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China
⨯

Cathepsin B aggravates atherosclerosis in ApoE-deficient mice by modulating vascular smooth muscle cell pyroptosis through NF-κB / NLRP3 signaling pathway

Hui Li,
Quanwei Zhao,
Danan Liu,
Bo Zhou,
Fujun Liao,
Long Chen

x

Published: January 2, 2024
https://doi.org/10.1371/journal.pone.0294514

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Transcription factors
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Diet
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Aorta
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Atherosclerosis
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DAPI staining
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Inflammasomes
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Immunofluorescence staining
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Smooth muscle cells
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