p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells

Shuta Tamura; Hiroshi Tazawa; Naoto Hori; Yuncheng Li; Motohiko Yamada; Satoru Kikuchi; Shinji Kuroda; Yasuo Urata; Shunsuke Kagawa; Toshiyoshi Fujiwara

doi:10.1371/journal.pone.0294491

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Open Access

Peer-reviewed

Research Article

p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells

Shuta Tamura,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hiroshi Tazawa ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: htazawa@md.okayama-u.ac.jp

Affiliations Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan

https://orcid.org/0000-0003-4658-1050

⨯
Naoto Hori,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Yuncheng Li,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Motohiko Yamada,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Satoru Kikuchi,

Roles Supervision

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Shinji Kuroda,

Roles Supervision

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

https://orcid.org/0000-0002-4484-1253

⨯
Yasuo Urata,

Roles Resources

Affiliation Oncolys BioPharma, Inc., Tokyo, Japan
⨯
Shunsuke Kagawa,

Roles Conceptualization, Supervision

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Toshiyoshi Fujiwara

Roles Conceptualization, Project administration, Writing – original draft, Writing – review & editing

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯

p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells

Shuta Tamura,
Hiroshi Tazawa,
Naoto Hori,
Yuncheng Li,
Motohiko Yamada,
Satoru Kikuchi,
Shinji Kuroda,
Yasuo Urata,
Shunsuke Kagawa,
Toshiyoshi Fujiwara

Published: November 16, 2023
https://doi.org/10.1371/journal.pone.0294491

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Autophagic cell death
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Colorectal cancer
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Apoptosis
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Cancer treatment
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Oncolytic viruses
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Adenoviruses
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HT29 cells
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Cell signaling
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