Validation of a highly sensitive HaloTag-based assay to evaluate the potency of a novel class of allosteric β-Galactosidase correctors

• Mikhail Rudinskiy ,

  Contributed equally to this work with: Mikhail Rudinskiy, Maria Pons-Vizcarra

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations Università Della Svizzera Italiana, Lugano, Switzerland, Department of Biology, Swiss Federal Institute of Technology, Zurich, Switzerland, Institute for Research in Biomedicine, Bellinzona, Switzerland

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• Maria Pons-Vizcarra ,

  Contributed equally to this work with: Mikhail Rudinskiy, Maria Pons-Vizcarra

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Gain Therapeutics Sucursal en España, Parc Científic de Barcelona, Barcelona, Spain

  https://orcid.org/0000-0001-5008-5741

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• Tatiana Soldà,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliations Università Della Svizzera Italiana, Lugano, Switzerland, Institute for Research in Biomedicine, Bellinzona, Switzerland

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• Ilaria Fregno,

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations Università Della Svizzera Italiana, Lugano, Switzerland, Institute for Research in Biomedicine, Bellinzona, Switzerland

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• Timothy Jan Bergmann,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Università Della Svizzera Italiana, Lugano, Switzerland, Institute for Research in Biomedicine, Bellinzona, Switzerland

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• Ana Ruano,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Gain Therapeutics Sucursal en España, Parc Científic de Barcelona, Barcelona, Spain

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• Aida Delgado,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Gain Therapeutics Sucursal en España, Parc Científic de Barcelona, Barcelona, Spain

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• Sara Morales,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Gain Therapeutics Sucursal en España, Parc Científic de Barcelona, Barcelona, Spain

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• Xavier Barril,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliations Gain Therapeutics Sucursal en España, Parc Científic de Barcelona, Barcelona, Spain, Facultat de Farmacia, IBUB & IQTC, Universitat de Barcelona, Barcelona, Spain, Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain

  https://orcid.org/0000-0002-0281-1347

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• Manolo Bellotto,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation GT Gain Therapeutics SA, Lugano, Switzerland

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• Elena Cubero,

  Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Gain Therapeutics Sucursal en España, Parc Científic de Barcelona, Barcelona, Spain

  https://orcid.org/0000-0002-2239-6670

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• Ana María García-Collazo,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Gain Therapeutics Sucursal en España, Parc Científic de Barcelona, Barcelona, Spain

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• Natalia Pérez-Carmona ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  * E-mail: maurizio.molinari@irb.usi.ch (MM); nperez@gaintherapeutics.com (NPC)

  Affiliation Gain Therapeutics Sucursal en España, Parc Científic de Barcelona, Barcelona, Spain

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• Maurizio Molinari

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: maurizio.molinari@irb.usi.ch (MM); nperez@gaintherapeutics.com (NPC)

  Affiliations Università Della Svizzera Italiana, Lugano, Switzerland, Institute for Research in Biomedicine, Bellinzona, Switzerland, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

  https://orcid.org/0000-0002-7636-5829

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