Computational analysis of the functional and structural impact of the most deleterious missense mutations in the human Protein C

Mahvash Farajzadeh-Dehkordi; Ladan Mafakher; Abbas Harifi; Fatemeh Samiee-Rad; Babak Rahmani

doi:10.1371/journal.pone.0294417

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Open Access

Peer-reviewed

Research Article

Computational analysis of the functional and structural impact of the most deleterious missense mutations in the human Protein C

Mahvash Farajzadeh-Dehkordi,

Roles Conceptualization, Data curation, Investigation, Methodology, Software, Writing – original draft

Affiliations Cellular and Molecular Research Center, Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran, Department of Molecular Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
⨯
Ladan Mafakher,

Roles Conceptualization, Data curation, Investigation, Methodology, Software, Writing – review & editing

Affiliation Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
⨯
Abbas Harifi,

Roles Conceptualization, Data curation, Methodology, Software

Affiliation Department of Electrical and Computer Engineering, University of Hormozgan, Bandar Abbas, Iran
⨯
Fatemeh Samiee-Rad ,

Roles Conceptualization, Investigation, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: fsamieerad@gmail.com

Affiliations Cellular and Molecular Research Center, Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran, Department of Pathobiology, Faculty of Medical School, Qazvin University of Medical Sciences, Qazvin, Iran

https://orcid.org/0000-0001-6091-4347

⨯
Babak Rahmani

Roles Conceptualization, Data curation, Methodology, Writing – review & editing

Affiliations Cellular and Molecular Research Center, Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran, Department of Molecular Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
⨯

Computational analysis of the functional and structural impact of the most deleterious missense mutations in the human Protein C

Mahvash Farajzadeh-Dehkordi,
Ladan Mafakher,
Abbas Harifi,
Fatemeh Samiee-Rad,
Babak Rahmani

Published: November 28, 2023
https://doi.org/10.1371/journal.pone.0294417

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Protein structure
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Protein structure comparison
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Biochemical simulations
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Protein domains
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Single nucleotide polymorphisms
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Molecular dynamics
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Protein structure prediction
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Protein structure determination
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