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Open Access
Peer-reviewed
Lab Protocol
A rapid, low-cost, and highly sensitive SARS-CoV-2 diagnostic based on whole-genome sequencing
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Per A. Adastra,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Writing – original draft, Writing – review & editing
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America
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Neva C. Durand,
Roles Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
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Namita Mitra,
Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America
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Saul Godinez Pulido,
Roles Investigation, Methodology, Validation, Writing – review & editing
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America
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Ragini Mahajan,
Roles Conceptualization, Methodology, Visualization, Writing – review & editing
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America, Department of Biosciences, Rice University, Houston, Texas, United States of America
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Alyssa Blackburn,
Roles Software, Validation, Writing – review & editing
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America
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Zane L. Colaric,
Roles Conceptualization, Investigation, Methodology, Validation, Writing – review & editing
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America
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Joshua W. M. Theisen,
Roles Conceptualization, Investigation, Methodology, Writing – review & editing
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America, Departments of Pediatrics, Pathology, Human Genetics, and Genetic Medicine, The University of Chicago, Chicago, Illinois, United States of America
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David Weisz,
Roles Data curation, Investigation, Resources, Software, Writing – review & editing
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America
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Olga Dudchenko,
Roles Conceptualization, Formal analysis, Supervision, Validation, Writing – review & editing
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America
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Andreas Gnirke,
Roles Conceptualization, Methodology, Supervision, Writing – review & editing
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
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Suhas S. P. Rao,
Roles Formal analysis, Methodology, Validation, Writing – review & editing
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America, Department of Structural Biology, Stanford University School of Medicine, Stanford, California, United States of America
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Parwinder Kaur,
Roles Formal analysis, Funding acquisition, Resources, Supervision, Writing – review & editing
Affiliation UWA School of Agriculture and Environment, The University of Western Australia, Crawley, Western Australia, Australia
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Erez Lieberman Aiden ,
Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing
* E-mail: Erez.Lieberman@bcm.edu (ELA); anilidodi@gmail.com (APA)
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America, Departments of Computer Science and Computational and Applied Mathematics, Rice University, Houston, Texas, United States of America
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Aviva Presser Aiden
Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: Erez.Lieberman@bcm.edu (ELA); anilidodi@gmail.com (APA)
Affiliations The Center for Genome Architecture, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Bioengineering, Rice University, Houston, Texas, United States of America, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America
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A rapid, low-cost, and highly sensitive SARS-CoV-2 diagnostic based on whole-genome sequencing
- Per A. Adastra,
- Neva C. Durand,
- Namita Mitra,
- Saul Godinez Pulido,
- Ragini Mahajan,
- Alyssa Blackburn,
- Zane L. Colaric,
- Joshua W. M. Theisen,
- David Weisz,
- Olga Dudchenko
- Published: November 30, 2023
- https://doi.org/10.1371/journal.pone.0294283
- See the preprint