Estrogen inhibits colonic smooth muscle contractions by regulating BKβ1 signaling

Jing Wen; Yu Zhao; Cheng Huang; Shengjie Li; Peidong Li; Yu Zhou; Zaihua Yan; Guangjun Zhang

doi:10.1371/journal.pone.0294249

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Open Access

Peer-reviewed

Research Article

Estrogen inhibits colonic smooth muscle contractions by regulating BKβ1 signaling

Jing Wen ,

Contributed equally to this work with: Jing Wen, Yu Zhao

Roles Writing – original draft

Affiliations The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, Institute of Hepatobiliary, Pancreatic and Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan, China
⨯
Yu Zhao ,

Contributed equally to this work with: Jing Wen, Yu Zhao

Roles Writing – original draft

Affiliations The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, Institute of Hepatobiliary, Pancreatic and Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan, China
⨯
Cheng Huang,

Roles Data curation, Methodology

Affiliations The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, Institute of Hepatobiliary, Pancreatic and Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan, China
⨯
Shengjie Li,

Roles Data curation, Methodology

Affiliations The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, Institute of Hepatobiliary, Pancreatic and Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan, China
⨯
Peidong Li,

Roles Data curation, Methodology

Affiliations The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, Institute of Hepatobiliary, Pancreatic and Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan, China
⨯
Yu Zhou,

Roles Data curation, Methodology

Affiliations The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, Institute of Hepatobiliary, Pancreatic and Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan, China
⨯
Zaihua Yan,

Roles Data curation, Methodology

Affiliations The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, Institute of Hepatobiliary, Pancreatic and Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan, China
⨯
Guangjun Zhang

Roles Writing – review & editing

* E-mail: zhanggj1977@126.com

Affiliations The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, Institute of Hepatobiliary, Pancreatic and Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan, China

https://orcid.org/0000-0002-6934-638X

⨯

Estrogen inhibits colonic smooth muscle contractions by regulating BKβ1 signaling

Jing Wen,
Yu Zhao,
Cheng Huang,
Shengjie Li,
Peidong Li,
Yu Zhou,
Zaihua Yan,
Guangjun Zhang

Published: November 10, 2023
https://doi.org/10.1371/journal.pone.0294249

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Colon
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Smooth muscles
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Muscle contraction
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Estrogens
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Fluorescence imaging
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Quantitative analysis
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Calcium-activated potassium channels
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