TGF-β inhibitor treatment of H₂O₂-induced cystitis models provides biochemical mechanism for elucidating interstitial cystitis/painful bladder syndrome patients

Hideto Taga; Tsunao Kishida; Yuta Inoue; Kenta Yamamoto; Shin-ichiro Kotani; Tsujimoto Masashi; Osamu Ukimura; Osam Mazda

doi:10.1371/journal.pone.0293983

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Open Access

Peer-reviewed

Research Article

TGF-β inhibitor treatment of H₂O₂-induced cystitis models provides biochemical mechanism for elucidating interstitial cystitis/painful bladder syndrome patients

Hideto Taga,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

Affiliations Department of Immunology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan, Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan

https://orcid.org/0009-0003-1463-8152

⨯
Tsunao Kishida,

Roles Conceptualization, Methodology, Supervision

Affiliation Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan
⨯
Yuta Inoue ,

Roles Conceptualization, Supervision

* E-mail: u-turn-n@koto.kpu-m.ac.jp

Affiliations Department of Immunology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan, Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan

https://orcid.org/0000-0002-0809-895X

⨯
Kenta Yamamoto,

Roles Data curation, Formal analysis

Affiliation Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan
⨯
Shin-ichiro Kotani,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan
⨯
Tsujimoto Masashi,

Roles Investigation

Affiliations Department of Immunology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan, Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan
⨯
Osamu Ukimura,

Roles Conceptualization, Writing – review & editing

Affiliation Department of Immunology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan
⨯
Osam Mazda

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan
⨯

TGF-β inhibitor treatment of H₂O₂-induced cystitis models provides biochemical mechanism for elucidating interstitial cystitis/painful bladder syndrome patients

Hideto Taga,
Tsunao Kishida,
Yuta Inoue,
Kenta Yamamoto,
Shin-ichiro Kotani,
Tsujimoto Masashi,
Osamu Ukimura,
Osam Mazda

Published: November 6, 2023
https://doi.org/10.1371/journal.pone.0293983

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