Head-to-head comparison of composite and individual biomarkers to predict clinical benefit to PD-1 blockade in non-small cell lung cancer

Karlijn Hummelink; Vincent van der Noort; Mirte Muller; Robert D. Schouten; Michel M. van den Heuvel; Daniela S. Thommen; Egbert F. Smit; Gerrit A. Meijer; Kim Monkhorst

doi:10.1371/journal.pone.0293707

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Open Access

Peer-reviewed

Research Article

Head-to-head comparison of composite and individual biomarkers to predict clinical benefit to PD-1 blockade in non-small cell lung cancer

Karlijn Hummelink ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: k.monkhorst@nki.nl (KM); k.hummelink@nki.nl (KH)

Affiliations Department of Pathology, Division of Diagnostic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands, Department of Thoracic Oncology, Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands

https://orcid.org/0000-0003-4371-8904

⨯
Vincent van der Noort,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Writing – review & editing

Affiliation Department of Biometrics, Netherlands Cancer Institute, Amsterdam, The Netherlands

https://orcid.org/0000-0002-4910-4535

⨯
Mirte Muller,

Roles Data curation, Resources, Writing – review & editing

Affiliation Department of Thoracic Oncology, Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
Robert D. Schouten,

Roles Data curation, Resources, Writing – review & editing

Affiliation Department of Thoracic Oncology, Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands

https://orcid.org/0000-0002-7014-470X

⨯
Michel M. van den Heuvel,

Roles Conceptualization, Data curation, Resources, Writing – review & editing

Current address: Department of Pulmonary Diseases, Radboud University Medical Center, Nijmegen, The Netherlands

Affiliation Department of Thoracic Oncology, Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands

https://orcid.org/0000-0002-6372-2153

⨯
Daniela S. Thommen,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands

https://orcid.org/0000-0002-7431-2854

⨯
Egbert F. Smit,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

Current address: Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, The Netherlands

Affiliation Department of Thoracic Oncology, Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands

https://orcid.org/0000-0002-7329-6995

⨯
Gerrit A. Meijer,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Pathology, Division of Diagnostic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
Kim Monkhorst

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: k.monkhorst@nki.nl (KM); k.hummelink@nki.nl (KH)

Affiliation Department of Pathology, Division of Diagnostic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯

Head-to-head comparison of composite and individual biomarkers to predict clinical benefit to PD-1 blockade in non-small cell lung cancer

Karlijn Hummelink,
Vincent van der Noort,
Mirte Muller,
Robert D. Schouten,
Michel M. van den Heuvel,
Daniela S. Thommen,
Egbert F. Smit,
Gerrit A. Meijer,
Kim Monkhorst

Published: July 31, 2024
https://doi.org/10.1371/journal.pone.0293707

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Non-small cell lung cancer
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Immunohistochemistry techniques
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