Reducing target binding affinity improves the therapeutic index of anti-MET antibody-drug conjugate in tumor bearing animals

Amita Datta-Mannan; Hiuwan Choi; Zhaoyan Jin; Ling Liu; Jirong Lu; David J. Stokell; Anthony T. Murphy; Kenneth W. Dunn; Michelle M. Martinez; Yiqing Feng

doi:10.1371/journal.pone.0293703

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Open Access

Peer-reviewed

Research Article

Reducing target binding affinity improves the therapeutic index of anti-MET antibody-drug conjugate in tumor bearing animals

Amita Datta-Mannan ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: datta_amita@lilly.com

Affiliation Exploratory Medicine and Pharmacology, Lilly Corporate Center, Indianapolis, IN, United States of America

https://orcid.org/0000-0003-2365-5360

⨯
Hiuwan Choi,

Roles Data curation, Methodology

Affiliation Bioproduct Research & Development, Lilly Technology Center North, Indianapolis, IN, United States of America
⨯
Zhaoyan Jin,

Roles Data curation, Formal analysis

Affiliation Drug Disposition/Commercialization, Lilly Corporate Center, Indianapolis, IN, United States of America
⨯
Ling Liu,

Roles Conceptualization

Affiliation Biotechnology Discovery Research, Lilly Technology Center North, Indianapolis, IN, United States of America
⨯
Jirong Lu,

Roles Conceptualization

Affiliation Biotechnology Discovery Research, Lilly Technology Center North, Indianapolis, IN, United States of America
⨯
David J. Stokell,

Roles Data curation, Formal analysis, Methodology

Affiliation Biotechnology Discovery Research, Lilly Technology Center North, Indianapolis, IN, United States of America
⨯
Anthony T. Murphy,

Roles Data curation, Formal analysis, Methodology

Affiliation Drug Disposition/Commercialization, Lilly Corporate Center, Indianapolis, IN, United States of America
⨯
Kenneth W. Dunn,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision

Affiliation Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, United States of America
⨯
Michelle M. Martinez,

Roles Data curation, Formal analysis

Affiliation Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, United States of America
⨯
Yiqing Feng

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

Affiliation Biotechnology Discovery Research, Lilly Technology Center North, Indianapolis, IN, United States of America
⨯

Reducing target binding affinity improves the therapeutic index of anti-MET antibody-drug conjugate in tumor bearing animals

Amita Datta-Mannan,
Hiuwan Choi,
Zhaoyan Jin,
Ling Liu,
Jirong Lu,
David J. Stokell,
Anthony T. Murphy,
Kenneth W. Dunn,
Michelle M. Martinez,
Yiqing Feng

Published: April 17, 2024
https://doi.org/10.1371/journal.pone.0293703

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