Levodopa-induced dyskinesia in early-onset Parkinson’s disease (EOPD) associates with glucocerebrosidase mutation: A next-generation sequencing study in EOPD patients in Thailand

Sekh Thanprasertsuk; Prasit Phowthongkum; Thitipong Hopetrungraung; Chalalai Poorirerngpoom; Tikumphorn Sathirapatya; Patsorn Wichit; Onanong Phokaewvarangkul; Kornkiat Vongpaisarnsin; Saknan Bongsebandhu-phubhakdi; Roongroj Bhidayasiri

doi:10.1371/journal.pone.0293516

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Peer-reviewed

Research Article

Levodopa-induced dyskinesia in early-onset Parkinson’s disease (EOPD) associates with glucocerebrosidase mutation: A next-generation sequencing study in EOPD patients in Thailand

Sekh Thanprasertsuk,

Roles Conceptualization, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Cognitive Clinical & Computational Neuroscience (CCCN) Center of Excellence, Chulalongkorn University, Bangkok, Thailand, Chula Neuroscience Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
⨯
Prasit Phowthongkum,

Roles Data curation, Writing – review & editing

Affiliations Division of Medical Genetics and Genomics, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Excellence Center of Genomics and Precision Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
⨯
Thitipong Hopetrungraung,

Roles Data curation, Writing – review & editing

Affiliations Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Department of Medicine, Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand
⨯
Chalalai Poorirerngpoom,

Roles Data curation, Writing – review & editing

Affiliations Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Saraburi Hospital, Saraburi, Thailand
⨯
Tikumphorn Sathirapatya,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliations Department of Forensic Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Forensic Genetics Research Unit, Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Patsorn Wichit,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliations Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Faculty of Physical Therapy, Huachiew Chalermprakiet University, Samut Prakan, Thailand
⨯
Onanong Phokaewvarangkul,

Roles Conceptualization, Writing – review & editing

Affiliations Chula Neuroscience Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand, Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Chulalongkorn Centre of Excellence for Parkinson’s Disease and Related Disorders, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
⨯
Kornkiat Vongpaisarnsin,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliations Department of Forensic Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Forensic Genetics Research Unit, Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Saknan Bongsebandhu-phubhakdi ,

Roles Conceptualization, Data curation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: saknan@live.jp

Affiliations Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Chula Neuroscience Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand

https://orcid.org/0000-0003-2357-3568

⨯
Roongroj Bhidayasiri

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Chula Neuroscience Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand, Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Chulalongkorn Centre of Excellence for Parkinson’s Disease and Related Disorders, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, The Academy of Science, The Royal Society of Thailand, Bangkok, Thailand
⨯

Levodopa-induced dyskinesia in early-onset Parkinson’s disease (EOPD) associates with glucocerebrosidase mutation: A next-generation sequencing study in EOPD patients in Thailand

Sekh Thanprasertsuk,
Prasit Phowthongkum,
Thitipong Hopetrungraung,
Chalalai Poorirerngpoom,
Tikumphorn Sathirapatya,
Patsorn Wichit,
Onanong Phokaewvarangkul,
Kornkiat Vongpaisarnsin,
Saknan Bongsebandhu-phubhakdi,
Roongroj Bhidayasiri

Published: October 31, 2023
https://doi.org/10.1371/journal.pone.0293516

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