Multiplexed assay of variant effect reveals residues of functional importance in the BRCA1 coiled-coil and serine cluster domains

• Gregory Nagy,

  Roles Conceptualization, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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• Mariame Diabate,

  Roles Data curation, Formal analysis, Visualization

  Affiliation Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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• Tapahsama Banerjee,

  Roles Investigation, Supervision

  Affiliation Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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• Aleksandra I. Adamovich,

  Roles Conceptualization, Investigation, Supervision, Writing – review & editing

  Current address: Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  Affiliation Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

  https://orcid.org/0000-0001-7207-0241

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• Nahum Smith,

  Roles Data curation, Formal analysis, Validation

  Affiliation Department of Genome Sciences, University of Washington and Brotman Baty Institute for Precision Medicine, Seattle, Washington, United States of America

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• Hyeongseon Jeon,

  Roles Data curation, Formal analysis, Validation

  Affiliation Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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• Shruti Dhar,

  Roles Investigation

  Affiliation Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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• Wenfang Liu,

  Roles Investigation

  Current address: Department of Molecular Genetics, College of Arts and Sciences, Ohio State University, Columbus, Ohio, United States of America

  Affiliation Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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• Katherine Burgess,

  Roles Investigation

  Affiliation Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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• Dongjun Chung,

  Roles Supervision

  Affiliation Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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• Lea M. Starita,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources

  Affiliation Department of Genome Sciences, University of Washington and Brotman Baty Institute for Precision Medicine, Seattle, Washington, United States of America

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• Jeffrey D. Parvin

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: Jeffrey.Parvin@osumc.edu

  Affiliation Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

  https://orcid.org/0000-0001-5616-1928

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