The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells

Julia Kalashova; Chenglu Yang; Hongmei Li; Yan Long; Duo Yu; Ting Zhang; Xumei Liu; Namrta Choudhry; Qiong Shi; Thaddeus D. Allen

doi:10.1371/journal.pone.0293283

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Open Access

Peer-reviewed

Research Article

The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells

Julia Kalashova ,

Contributed equally to this work with: Julia Kalashova, Chenglu Yang

Roles Conceptualization, Data curation, Methodology, Writing – original draft

Affiliations Division of Discovery Oncology, Chengdu Anticancer Bioscience, Chengdu, Sichuan, China, Department of Basic Cancer Research, J. Michael Bishop Institute of Cancer Research, Chengdu, Sichuan, China
⨯
Chenglu Yang ,

Contributed equally to this work with: Julia Kalashova, Chenglu Yang

Roles Data curation, Methodology, Writing – original draft

Affiliations Division of Discovery Oncology, Chengdu Anticancer Bioscience, Chengdu, Sichuan, China, Department of Basic Cancer Research, J. Michael Bishop Institute of Cancer Research, Chengdu, Sichuan, China
⨯
Hongmei Li,

Roles Data curation

Affiliations Division of Discovery Oncology, Chengdu Anticancer Bioscience, Chengdu, Sichuan, China, Department of Basic Cancer Research, J. Michael Bishop Institute of Cancer Research, Chengdu, Sichuan, China
⨯
Yan Long,

Roles Data curation

Affiliations Division of Discovery Oncology, Chengdu Anticancer Bioscience, Chengdu, Sichuan, China, Department of Basic Cancer Research, J. Michael Bishop Institute of Cancer Research, Chengdu, Sichuan, China
⨯
Duo Yu,

Roles Data curation

Affiliation Division of Discovery Oncology, Chengdu Anticancer Bioscience, Chengdu, Sichuan, China
⨯
Ting Zhang,

Roles Conceptualization, Data curation, Methodology

Affiliations Division of Discovery Oncology, Chengdu Anticancer Bioscience, Chengdu, Sichuan, China, Department of Basic Cancer Research, J. Michael Bishop Institute of Cancer Research, Chengdu, Sichuan, China
⨯
Xumei Liu,

Roles Data curation

Affiliation Division of Discovery Oncology, Chengdu Anticancer Bioscience, Chengdu, Sichuan, China
⨯
Namrta Choudhry,

Roles Writing – review & editing

Affiliations Division of Discovery Oncology, Chengdu Anticancer Bioscience, Chengdu, Sichuan, China, Department of Basic Cancer Research, J. Michael Bishop Institute of Cancer Research, Chengdu, Sichuan, China
⨯
Qiong Shi ,

Roles Conceptualization, Data curation, Writing – original draft, Writing – review & editing

* E-mail: qshi@anticancerbio.com (QS); tallen@anticancerbio.com (TDA)

Affiliations Division of Discovery Oncology, Chengdu Anticancer Bioscience, Chengdu, Sichuan, China, Department of Basic Cancer Research, J. Michael Bishop Institute of Cancer Research, Chengdu, Sichuan, China
⨯
Thaddeus D. Allen

Roles Conceptualization, Writing – original draft, Writing – review & editing

* E-mail: qshi@anticancerbio.com (QS); tallen@anticancerbio.com (TDA)

Affiliations Division of Discovery Oncology, Chengdu Anticancer Bioscience, Chengdu, Sichuan, China, Department of Basic Cancer Research, J. Michael Bishop Institute of Cancer Research, Chengdu, Sichuan, China

https://orcid.org/0000-0002-4268-3394

⨯

The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells

Julia Kalashova,
Chenglu Yang,
Hongmei Li,
Yan Long,
Duo Yu,
Ting Zhang,
Xumei Liu,
Namrta Choudhry,
Qiong Shi,
Thaddeus D. Allen

Published: October 30, 2023
https://doi.org/10.1371/journal.pone.0293283

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