The indole motif is essential for the antitrypanosomal activity of N⁵-substituted paullones

• Irina Ihnatenko,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliations Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, Braunschweig, Germany, PVZ–Center of Pharmaceutical Engineering, TU Braunschweig, Braunschweig, Germany

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• Marco J. Müller,

  Roles Methodology, Writing – review & editing

  Affiliations Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, Braunschweig, Germany, PVZ–Center of Pharmaceutical Engineering, TU Braunschweig, Braunschweig, Germany

  https://orcid.org/0000-0003-4019-6653

  ⨯
• Oliver C. F. Orban,

  Roles Methodology, Writing – review & editing

  Affiliations Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, Braunschweig, Germany, PVZ–Center of Pharmaceutical Engineering, TU Braunschweig, Braunschweig, Germany

  ⨯
• Jens C. Lindhof,

  Roles Methodology, Writing – review & editing

  Affiliations Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, Braunschweig, Germany, PVZ–Center of Pharmaceutical Engineering, TU Braunschweig, Braunschweig, Germany

  ⨯
• Diego Benítez,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay

  ⨯
• Cecilia Ortíz,

  Roles Investigation, Methodology

  Affiliation Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay

  https://orcid.org/0000-0002-1096-0326

  ⨯
• Estefanía Dibello,

  Roles Investigation, Methodology

  Affiliations Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay, Laboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay

  ⨯
• Leonardo L. Seidl,

  Roles Investigation, Methodology

  Affiliation Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay

  https://orcid.org/0000-0001-9591-278X

  ⨯
• Marcelo A. Comini ,

  Contributed equally to this work with: Marcelo A. Comini, Conrad Kunick

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay

  https://orcid.org/0000-0001-5000-1333

  ⨯
• Conrad Kunick

  Contributed equally to this work with: Marcelo A. Comini, Conrad Kunick

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: c.kunick@tu-braunschweig.de

  Affiliations Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, Braunschweig, Germany, PVZ–Center of Pharmaceutical Engineering, TU Braunschweig, Braunschweig, Germany

  https://orcid.org/0000-0001-7041-5322

  ⨯