Oral angiotensin-converting enzyme inhibitor captopril protects the heart from Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice

• Kenichi Kiyomoto ,

  Contributed equally to this work with: Kenichi Kiyomoto, Ichiro Matsuo

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliations Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan, Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, Japan

  ⨯
• Ichiro Matsuo ,

  Contributed equally to this work with: Kenichi Kiyomoto, Ichiro Matsuo

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft

  Affiliation Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, Japan

  ⨯
• Kenji Suita,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology

  Affiliation Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

  ⨯
• Yoshiki Ohnuki,

  Roles Conceptualization, Funding acquisition, Methodology

  Affiliation Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

  ⨯
• Misao Ishikawa,

  Roles Methodology

  Affiliation Department of Oral Anatomy, Tsurumi University School of Dental Medicine, Yokohama, Japan

  ⨯
• Aiko Ito,

  Roles Funding acquisition

  Affiliation Department of Orthodontology, Tsurumi University School of Dental Medicine, Yokohama, Japan

  ⨯
• Yasumasa Mototani,

  Roles Methodology

  Affiliation Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

  ⨯
• Michinori Tsunoda,

  Roles Investigation

  Affiliations Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan, Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, Japan

  ⨯
• Akinaka Morii,

  Roles Investigation

  Affiliations Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan, Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, Japan

  ⨯
• Megumi Nariyama,

  Roles Funding acquisition

  Affiliation Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine, Yokohama, Japan

  ⨯
• Yoshio Hayakawa,

  Roles Investigation

  Affiliation Department of Dental Anesthesiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

  ⨯
• Yasuharu Amitani,

  Roles Formal analysis

  Affiliation Department of Mathematics, Tsurumi University School of Dental Medicine, Yokohama, Japan

  ⨯
• Kazuhiro Gomi,

  Roles Supervision

  Affiliation Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, Japan

  ⨯
• Satoshi Okumura

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft

  * E-mail: okumura-s@tsurumi-u.ac.jp

  Affiliation Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

  https://orcid.org/0000-0001-8747-7941

  ⨯