Age-related changes in the hematopoietic stem cell pool revealed via quantifying the balance of symmetric and asymmetric divisions

• Teiko Kawahigashi ,

  Contributed equally to this work with: Teiko Kawahigashi, Shoya Iwanami

  Roles Data curation, Formal analysis, Investigation, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Division of Stem Cell Biology, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan

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• Shoya Iwanami ,

  Contributed equally to this work with: Teiko Kawahigashi, Shoya Iwanami

  Roles Formal analysis, Resources

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan

  https://orcid.org/0000-0003-1474-5348

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• Munetomo Takahashi,

  Roles Conceptualization, Writing – original draft

  Affiliations Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo, Japan, Medical Research Council Toxicology Unit, Gleeson Building, Tennis Court Road, University of Cambridge, Cambridge, United Kingdom

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• Joydeep Bhadury,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United States of America

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• Shingo Iwami ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision

  * E-mail: iwami.iblab@bio.nagoya-u.ac.jp (SI); y-sato4@md.tsukuba.ac.jp (SY)

  Affiliations interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan, Institute of Mathematics for Industry, Kyushu University, Fukuoka, Japan, Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan, Interdisciplinary Theoretical and Mathematical Sciences Program (iTHEMS), RIKEN, Saitama, Japan, NEXT-Ganken Program, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan, Science Groove Inc., Fukuoka, Japan

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• Satoshi Yamazaki

  Roles Supervision, Writing – original draft, Writing – review & editing

  * E-mail: iwami.iblab@bio.nagoya-u.ac.jp (SI); y-sato4@md.tsukuba.ac.jp (SY)

  Affiliations Division of Stem Cell Biology, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan, Laboratory of Stem Cell Therapy, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

  https://orcid.org/0000-0003-4249-3854

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