Deep coverage and quantification of the bone proteome provides enhanced opportunities for new discoveries in skeletal biology and disease

Jacob P. Rose; Charles A. Schurman; Christina D. King; Joanna Bons; Sandip K. Patel; Jordan B. Burton; Amy O’Broin; Tamara Alliston; Birgit Schilling

doi:10.1371/journal.pone.0292268

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Open Access

Peer-reviewed

Research Article

Deep coverage and quantification of the bone proteome provides enhanced opportunities for new discoveries in skeletal biology and disease

Jacob P. Rose,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Buck Institute for Research on Aging, Novato, CA, United States of America
⨯
Charles A. Schurman,

Roles Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

Affiliation Buck Institute for Research on Aging, Novato, CA, United States of America
⨯
Christina D. King,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Buck Institute for Research on Aging, Novato, CA, United States of America
⨯
Joanna Bons,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Buck Institute for Research on Aging, Novato, CA, United States of America
⨯
Sandip K. Patel,

Roles Formal analysis

Affiliation Buck Institute for Research on Aging, Novato, CA, United States of America
⨯
Jordan B. Burton,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Buck Institute for Research on Aging, Novato, CA, United States of America
⨯
Amy O’Broin,

Roles Formal analysis

Affiliation Buck Institute for Research on Aging, Novato, CA, United States of America
⨯
Tamara Alliston,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Visualization, Writing – review & editing

Affiliations Department of Orthopaedic Surgery, University of California, San Francisco, CA, Unted States of America, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States of America
⨯
Birgit Schilling

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing

* E-mail: bschilling@buckinstitute.org

Affiliation Buck Institute for Research on Aging, Novato, CA, United States of America

https://orcid.org/0000-0001-9907-2749

⨯

Deep coverage and quantification of the bone proteome provides enhanced opportunities for new discoveries in skeletal biology and disease

Jacob P. Rose,
Charles A. Schurman,
Christina D. King,
Joanna Bons,
Sandip K. Patel,
Jordan B. Burton,
Amy O’Broin,
Tamara Alliston,
Birgit Schilling

Published: October 10, 2023
https://doi.org/10.1371/journal.pone.0292268

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Protein extraction
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