Cinnamaldehyde alleviates doxorubicin-induced cardiotoxicity by decreasing oxidative stress and ferroptosis in cardiomyocytes

Meijiao Mao; Wang Zheng; Bin Deng; Youhua Wang; Duan Zhou; Lin Shen; Wankang Niku; Na Zhang

doi:10.1371/journal.pone.0292124

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Open Access

Peer-reviewed

Research Article

Cinnamaldehyde alleviates doxorubicin-induced cardiotoxicity by decreasing oxidative stress and ferroptosis in cardiomyocytes

Meijiao Mao ,

Contributed equally to this work with: Meijiao Mao, Wang Zheng

Roles Conceptualization, Methodology, Project administration, Writing – original draft, Writing – review & editing

* E-mail: amao1236@163.com (MM); lhzhna@163.com (NZ)

Affiliation Department of Cardiology, Longhua Hospital, ShangHai University of Traditional Chinese Medicine, Shanghai, China

https://orcid.org/0000-0002-7450-7053

⨯
Wang Zheng ,

Contributed equally to this work with: Meijiao Mao, Wang Zheng

Roles Conceptualization, Formal analysis, Funding acquisition

Affiliation Department of Cardiology, Longhua Hospital, ShangHai University of Traditional Chinese Medicine, Shanghai, China
⨯
Bin Deng,

Roles Funding acquisition

Affiliation Department of Cardiology, Longhua Hospital, ShangHai University of Traditional Chinese Medicine, Shanghai, China
⨯
Youhua Wang,

Roles Funding acquisition, Methodology

Affiliation Department of Cardiology, Longhua Hospital, ShangHai University of Traditional Chinese Medicine, Shanghai, China
⨯
Duan Zhou,

Roles Project administration

Affiliation Department of Cardiology, Longhua Hospital, ShangHai University of Traditional Chinese Medicine, Shanghai, China
⨯
Lin Shen,

Roles Investigation

Affiliation Department of Cardiology, Longhua Hospital, ShangHai University of Traditional Chinese Medicine, Shanghai, China
⨯
Wankang Niku,

Roles Data curation

Affiliation Department of Cardiology, Longhua Hospital, ShangHai University of Traditional Chinese Medicine, Shanghai, China
⨯
Na Zhang

Roles Data curation, Supervision, Writing – review & editing

* E-mail: amao1236@163.com (MM); lhzhna@163.com (NZ)

Affiliation Department of Cardiology, Longhua Hospital, ShangHai University of Traditional Chinese Medicine, Shanghai, China

https://orcid.org/0009-0005-4218-819X

⨯

Cinnamaldehyde alleviates doxorubicin-induced cardiotoxicity by decreasing oxidative stress and ferroptosis in cardiomyocytes

Meijiao Mao,
Wang Zheng,
Bin Deng,
Youhua Wang,
Duan Zhou,
Lin Shen,
Wankang Niku,
Na Zhang

Published: October 12, 2023
https://doi.org/10.1371/journal.pone.0292124

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Oxidative stress
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Cardiomyocytes
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Calcium signaling
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Hepatocellular carcinoma
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Redox signaling
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