Application of transfer learning to predict drug-induced human in vivo gene expression changes using rat in vitro and in vivo data

• Shauna D. O’Donovan ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: s.d.odonovan@tue.nl

  Affiliations Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands, Dept. of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands, Eindhoven Artificial Intelligence Systems Institute (EAISI), Eindhoven University of Technology, Eindhoven, The Netherlands

  https://orcid.org/0000-0003-2253-4903

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• Rachel Cavill,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Dept. of Advanced Computing Sciences, Maastricht University, Maastricht, The Netherlands

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• Florian Wimmenauer,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Writing – review & editing

  Affiliation Dept. of Advanced Computing Sciences, Maastricht University, Maastricht, The Netherlands

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• Alexander Lukas,

  Roles Data curation, Formal analysis, Resources, Software, Writing – review & editing

  Affiliation Dept. of Advanced Computing Sciences, Maastricht University, Maastricht, The Netherlands

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• Tobias Stumm,

  Roles Data curation, Formal analysis, Resources, Software, Writing – review & editing

  Affiliation Dept. of Advanced Computing Sciences, Maastricht University, Maastricht, The Netherlands

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• Evgueni Smirnov,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Dept. of Advanced Computing Sciences, Maastricht University, Maastricht, The Netherlands

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• Michael Lenz,

  Roles Conceptualization, Data curation, Methodology, Resources, Writing – review & editing

  Affiliations Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands, Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, Mainz, Germany, Preventive Cardiology and Preventative Medicine – Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

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• Gokhan Ertaylan,

  Roles Conceptualization, Writing – review & editing

  Affiliations Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands, Sustainable Health, Flemish Institute for Technological Research (VITO), Mol, Belgium

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• Danyel G. J. Jennen,

  Roles Conceptualization, Data curation, Resources, Writing – review & editing

  Affiliation Dept. of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands

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• Natal A. W. van Riel,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliations Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands, Dept. of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands, Eindhoven Artificial Intelligence Systems Institute (EAISI), Eindhoven University of Technology, Eindhoven, The Netherlands

  https://orcid.org/0000-0001-9375-4730

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• Kurt Driessens,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Dept. of Advanced Computing Sciences, Maastricht University, Maastricht, The Netherlands

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• Ralf L. M. Peeters,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliations Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands, Dept. of Advanced Computing Sciences, Maastricht University, Maastricht, The Netherlands

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• Theo M. C. M. de Kok

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliations Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands, Dept. of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands

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