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Open Access

Peer-reviewed

Research Article

Development of multi-drug resistance to anticancer drugs in HepG2 cells due to MRP2 upregulation on exposure to menthol

Katsuhito Nagai ,

Roles Writing – original draft

* E-mail: nagaika@osaka-ohtani.ac.jp

Affiliation Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan

https://orcid.org/0000-0003-0753-9861

⨯
Mayuko Tamura,

Roles Investigation

Affiliation Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan
⨯
Ryuga Murayama,

Roles Investigation

Affiliation Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan
⨯
Shuhei Fukuno,

Roles Investigation

Affiliation Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan
⨯
Takuya Ito,

Roles Conceptualization

Affiliation Laboratory of Natural Medicines, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan
⨯
Hiroki Konishi

Roles Writing – review & editing

Affiliation Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan
⨯

Development of multi-drug resistance to anticancer drugs in HepG2 cells due to MRP2 upregulation on exposure to menthol

Katsuhito Nagai,
Mayuko Tamura,
Ryuga Murayama,
Shuhei Fukuno,
Takuya Ito,
Hiroki Konishi

x

Published: September 21, 2023
https://doi.org/10.1371/journal.pone.0291822

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Cancer treatment
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Hepatocellular carcinoma
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Cytotoxicity
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Gene expression
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Irritable bowel syndrome
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Polymerase chain reaction
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