Nicotine flux as a powerful tool for regulating nicotine delivery from e-cigarettes: Protocol of two complimentary randomized crossover clinical trials

• Ahmad El-Hellani ,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: elhellani.1@osu.edu

  Affiliations Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio, United States of America, Center for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America

  https://orcid.org/0000-0002-1047-0597

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• Elyana Hanna,

  Roles Methodology, Project administration, Writing – review & editing

  Affiliations Department of Mechanical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon, Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Mehak Sharma,

  Roles Methodology, Project administration, Writing – review & editing

  Affiliation Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America

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• Reagan Blohowiak,

  Roles Methodology, Project administration, Writing – review & editing

  Affiliation Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America

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• Phillip Joseph,

  Roles Methodology, Project administration, Writing – review & editing

  Affiliation Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America

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• Tore Eid,

  Roles Methodology, Project administration, Writing – review & editing

  Affiliation Department of Laboratory Medicine, Yale School of Medicine, Washington, DC, United States of America

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• Haleh Nadim,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Laboratory Medicine, Yale School of Medicine, Washington, DC, United States of America

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• Rachel El-Hage,

  Roles Methodology, Project administration, Writing – review & editing

  Affiliations Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Chemistry, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon

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• Rola Salman,

  Roles Methodology, Project administration, Writing – review & editing

  Affiliations Department of Mechanical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon, Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Nareg Karaoghlanian,

  Roles Methodology, Software, Writing – review & editing

  Affiliations Department of Mechanical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon, Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Ayomipo Adeniji,

  Roles Methodology, Writing – review & editing

  Affiliations Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio, United States of America, Center for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America

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• Sally Salam,

  Roles Methodology, Project administration, Writing – review & editing

  Affiliations Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Chemistry, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon

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• Farid Talih,

  Roles Investigation, Writing – review & editing

  Affiliation Clinical Psychiatry, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

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• Martine Elbejjani,

  Roles Data curation, Formal analysis, Software, Writing – review & editing

  Affiliation Clinical Research Institute & Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

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• Alison Breland,

  Roles Conceptualization, Funding acquisition, Investigation, Writing – review & editing

  Affiliations Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Thomas Eissenberg,

  Roles Conceptualization, Funding acquisition, Investigation, Writing – review & editing

  Affiliations Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Alan Shihadeh,

  Roles Conceptualization, Funding acquisition, Investigation, Writing – review & editing

  Affiliations Department of Mechanical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon, Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Stephen R. Baldassarri,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America, Yale Center for the Study of Tobacco Product Use and Addiction, Yale University, New Haven, Connecticut, United States of America, Program in Addiction Medicine, Yale School of Medicine, Washington, DC, United States of America

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•  [ ... ],
• Soha Talih

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Mechanical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon, Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, United States of America

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