Integrated analysis of phase 1a and 1b randomized controlled trials; Treg-targeted cancer immunotherapy with the humanized anti-CCR4 antibody, KW-0761, for advanced solid tumors

• Kaoru Fujikawa ,

  Contributed equally to this work with: Kaoru Fujikawa, Takuro Saito

  Roles Formal analysis, Visualization, Writing – original draft

  Affiliation Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Takuro Saito ,

  Contributed equally to this work with: Kaoru Fujikawa, Takuro Saito

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft

  Affiliation Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  https://orcid.org/0000-0002-1733-5064

  ⨯
• Koji Kurose,

  Roles Data curation, Investigation

  Affiliation Department of Respiratory Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan

  https://orcid.org/0000-0002-3878-1477

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• Takashi Kojima,

  Roles Data curation, Investigation

  Affiliation Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan

  ⨯
• Takeru Funakoshi,

  Roles Data curation, Investigation

  Affiliation Department of Dermatology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

  ⨯
• Eiichi Sato,

  Roles Investigation

  Affiliation Department of Pathology, Institute of Medical Science (Medical Research Center), Tokyo Medical University, Shinjuku-ku, Tokyo, Japan

  ⨯
• Kazuhiro Kakimi,

  Roles Data curation, Investigation

  Affiliation Department of Immunotherapeutics, The University of Tokyo Hospital, Bunkyo-Ku, Tokyo, Japan

  https://orcid.org/0000-0003-2631-3040

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• Shinsuke Iida,

  Roles Data curation, Investigation

  Affiliation Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan

  ⨯
• Yuichiro Doki,

  Roles Data curation, Investigation

  Affiliation Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Mikio Oka,

  Roles Data curation, Investigation

  Affiliation Department of Immuno-Oncology, Kawasaki Medical School, Kurashiki, Okayama, Japan

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• Ryuzo Ueda ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  * E-mail: rueda@med.nagoya-u.ac.jp (RU); hwada@gesurg.med.osaka-u.ac.jp (HW)

  Affiliation Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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• Hisashi Wada

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Writing – review & editing

  * E-mail: rueda@med.nagoya-u.ac.jp (RU); hwada@gesurg.med.osaka-u.ac.jp (HW)

  Affiliation Department of Clinical Research in Tumor Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  https://orcid.org/0000-0002-5444-6193

  ⨯