Safety and clinical efficacy of an anti-PD-L1 antibody (c4G12) in dogs with advanced malignant tumours

• Naoya Maekawa,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan, Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan

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• Satoru Konnai ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: konnai@vetmed.hokudai.ac.jp

  Affiliations Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan, Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan, Faculty of Veterinary Medicine, Department of Disease Control, Hokkaido University, Sapporo, Japan, Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan

  https://orcid.org/0000-0002-3230-7109

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• Kenji Hosoya,

  Roles Investigation, Methodology, Resources, Validation

  Affiliations Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan, Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan

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• Sangho Kim,

  Roles Investigation, Methodology, Resources, Validation

  Affiliations Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan, Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan

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• Ryohei Kinoshita,

  Roles Investigation, Methodology, Resources, Validation

  Affiliations Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan, Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan

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• Tatsuya Deguchi,

  Roles Investigation, Methodology, Resources

  Affiliations Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan, Department of Companion Animal Clinical Sciences, Companion Animal Internal Medicine, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan

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• Ryo Owaki,

  Roles Investigation, Methodology

  Affiliation Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan

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• Yurika Tachibana,

  Roles Investigation, Methodology

  Affiliation Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan

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• Madoka Yokokawa,

  Roles Investigation, Methodology

  Affiliation Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan

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• Hiroto Takeuchi,

  Roles Investigation, Methodology

  Affiliation Faculty of Veterinary Medicine, Department of Disease Control, Hokkaido University, Sapporo, Japan

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• Yumiko Kagawa,

  Roles Formal analysis, Investigation, Methodology, Resources, Validation

  Affiliation North Lab, Sapporo, Japan

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• Satoshi Takagi,

  Roles Conceptualization, Investigation, Methodology, Resources

  Affiliations Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan, Department of Veterinary Surgery 1, School of Veterinary Medicine, Azabu University, Sagamihara, Japan

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• Hiroshi Ohta,

  Roles Investigation, Methodology, Resources

  Affiliations Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Hokkaido University, Sapporo, Japan, Department of Companion Animal Clinical Sciences, Companion Animal Internal Medicine, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan

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• Yukinari Kato,

  Roles Methodology, Resources

  Affiliations Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan, Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan

  https://orcid.org/0000-0001-5385-8201

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• Satoshi Yamamoto,

  Roles Methodology, Resources

  Affiliations Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan, Fuso Pharmaceutical Industries, Ltd., Osaka, Japan

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• Keiichi Yamamoto,

  Roles Methodology, Resources

  Affiliations Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan, Fuso Pharmaceutical Industries, Ltd., Osaka, Japan

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• Yasuhiko Suzuki,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision

  Affiliations Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan, Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan, Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan

  https://orcid.org/0000-0002-1313-1494

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• Tomohiro Okagawa,

  Roles Conceptualization, Methodology, Resources, Supervision

  Affiliation Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan

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• Shiro Murata,

  Roles Conceptualization, Methodology, Resources, Supervision

  Affiliations Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan, Faculty of Veterinary Medicine, Department of Disease Control, Hokkaido University, Sapporo, Japan

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•  [ ... ],
• Kazuhiko Ohashi

  Roles Conceptualization, Data curation, Methodology, Project administration, Resources, Supervision

  Affiliations Faculty of Veterinary Medicine, Department of Advanced Pharmaceutics, Hokkaido University, Sapporo, Japan, Faculty of Veterinary Medicine, Department of Disease Control, Hokkaido University, Sapporo, Japan, Faculty of Veterinary Medicine, International Affairs Office, Hokkaido University, Sapporo, Japan

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