Ion exchange chromatography as a simple and scalable method to isolate biologically active small extracellular vesicles from conditioned media

• Ricardo Malvicini ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: rmalvicini@favaloro.edu.ar

  Affiliations Laboratorio de Regulación Génica y Células Madre, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Buenos Aires, Argentina, Department of Women’s and Children’s Health, University of Padova, Padua, Italy, Laboratory of Extracellular Vesicles as Therapeutic Tools, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Padua, Italy, L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Padua, Italy

  https://orcid.org/0000-0002-2764-6165

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• Diego Santa-Cruz,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Laboratorio de Regulación Génica y Células Madre, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Buenos Aires, Argentina

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• Anna Maria Tolomeo,

  Roles Data curation, Investigation

  Affiliations Laboratory of Extracellular Vesicles as Therapeutic Tools, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Padua, Italy, L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Padua, Italy, Department of Cardiac, Thoracic and Vascular Science and Public Health, University of Padova, Padua, Italy

  https://orcid.org/0000-0001-5077-0845

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• Maurizio Muraca,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft

  Affiliations Department of Women’s and Children’s Health, University of Padova, Padua, Italy, Laboratory of Extracellular Vesicles as Therapeutic Tools, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Padua, Italy, L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Padua, Italy

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• Gustavo Yannarelli ,

  Contributed equally to this work with: Gustavo Yannarelli, Natalia Pacienza

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Laboratorio de Regulación Génica y Células Madre, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Buenos Aires, Argentina

  https://orcid.org/0000-0003-1450-5483

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• Natalia Pacienza

  Contributed equally to this work with: Gustavo Yannarelli, Natalia Pacienza

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Laboratorio de Regulación Génica y Células Madre, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Buenos Aires, Argentina

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