An enhanced three-stage design with trend analysis for allergen immunotherapy trials

• Xinyu Tang ,

  Contributed equally to this work with: Xinyu Tang, Lihan K. Yan

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  * E-mail: Xinyu.Tang@fda.hhs.gov

  Affiliation Office of Biostatistics and Pharmacovigilance, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Silver Spring, MD, United States of America

  https://orcid.org/0000-0002-9618-4654

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• Ronald L. Rabin,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Office of Vaccines Research and Review, CBER, FDA, Silver Spring, MD, United States of America

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• Lihan K. Yan

  Contributed equally to this work with: Xinyu Tang, Lihan K. Yan

  Roles Conceptualization, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Office of Biostatistics and Pharmacovigilance, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Silver Spring, MD, United States of America

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