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Open Access
Peer-reviewed
Research Article
Evaluation of a human mucosal tissue explant model for SARS-CoV-2 replication
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Bhavna Gowan Gordhan ,
Contributed equally to this work with: Bhavna Gowan Gordhan, Carolina Herrera
Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing
Affiliation Faculty of Health Sciences, Department of Science and Innovation/National Research Foundation Centre of Excellence for Biomedical TB Research, School of Pathology, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa
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Carolina Herrera ,
Contributed equally to this work with: Bhavna Gowan Gordhan, Carolina Herrera
Roles Conceptualization, Methodology, Resources, Writing – review & editing
Affiliation Department of Infectious Disease, Imperial College London, London, United Kingdom
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Azure-Dee Pillay,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Faculty of Health Sciences, Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Johannesburg, South Africa
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Thabiso Seiphetlo,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Faculty of Health Sciences, Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Johannesburg, South Africa
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Christopher Shawn Ealand,
Roles Methodology, Writing – review & editing
Affiliation Faculty of Health Sciences, Department of Science and Innovation/National Research Foundation Centre of Excellence for Biomedical TB Research, School of Pathology, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa
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Edith Machowski,
Roles Methodology, Writing – review & editing
Affiliation Faculty of Health Sciences, Department of Science and Innovation/National Research Foundation Centre of Excellence for Biomedical TB Research, School of Pathology, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa
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Natasha Singh,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Faculty of Health Sciences, Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Johannesburg, South Africa
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Ntombexolo Seatholo,
Roles Resources
Affiliation Faculty of Health Sciences, Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Johannesburg, South Africa
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Kennedy Otwombe,
Roles Data curation, Writing – review & editing
Affiliations Faculty of Health Sciences, Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Johannesburg, South Africa, Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa
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Limakatso Lebina,
Roles Resources, Writing – review & editing
Affiliation Faculty of Health Sciences, Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Johannesburg, South Africa
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Rebecca Frise,
Roles Resources
Affiliation Department of Infectious Disease, Imperial College London, London, United Kingdom
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Gabriella Scarlatti,
Roles Methodology
Affiliation Viral Evolution and Transmission Unit, IRCCS Ospedale San Raffaele, Milan, Italy
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Francesca Chiodi,
Roles Conceptualization, Writing – review & editing
Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden
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Neil Martinson ,
Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing
¶‡ These authors also contributed equally to this work.
Affiliations Faculty of Health Sciences, Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Johannesburg, South Africa, Johns Hopkins University Center for TB Research, Baltimore, MD, United States of America
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Julie Fox ,
Roles Conceptualization, Funding acquisition, Writing – review & editing
¶‡ These authors also contributed equally to this work.
Affiliation Guys and St. Thomas’ NHS Foundation Trust and King’s College London, London, United Kingdom
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Bavesh Davandra Kana
Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: bavesh.kana@wits.ac.za
¶‡ These authors also contributed equally to this work.
Affiliation Faculty of Health Sciences, Department of Science and Innovation/National Research Foundation Centre of Excellence for Biomedical TB Research, School of Pathology, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa
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Evaluation of a human mucosal tissue explant model for SARS-CoV-2 replication
- Bhavna Gowan Gordhan,
- Carolina Herrera,
- Azure-Dee Pillay,
- Thabiso Seiphetlo,
- Christopher Shawn Ealand,
- Edith Machowski,
- Natasha Singh,
- Ntombexolo Seatholo,
- Kennedy Otwombe,
- Limakatso Lebina
- Published: September 28, 2023
- https://doi.org/10.1371/journal.pone.0291146