Probing the substrate binding modes and catalytic mechanisms of BLEG-1, a promiscuous B3 metallo-β-lactamase with glyoxalase II properties

• Shaw Xian Au ,

  Contributed equally to this work with: Shaw Xian Au, Azyyati Mohd Padzil, Yahaya M. Normi

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Enzyme and Microbial Technology (EMTech) Research Center, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia, Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

  https://orcid.org/0000-0002-2340-373X

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• Azyyati Mohd Padzil ,

  Contributed equally to this work with: Shaw Xian Au, Azyyati Mohd Padzil, Yahaya M. Normi

  Roles Formal analysis, Methodology, Validation

  Affiliation Malaysia Genome and Vaccine Institute, National Institutes of Biotechnology Malaysia, Jalan Bangi, Kajang, Selangor, Malaysia

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• Noor Dina Muhd Noor ,

  Roles Supervision, Writing – review & editing

  ¶‡ NDMN, HM and RNZRAR also contributed equally to this work.

  Affiliations Enzyme and Microbial Technology (EMTech) Research Center, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia, Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

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• Hiroyoshi Matsumura ,

  Roles Supervision, Writing – review & editing

  ¶‡ NDMN, HM and RNZRAR also contributed equally to this work.

  Affiliation College of Life Sciences, Ritsumeikan University, Noji-Higashi, Kusatsu, Japan

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• Raja Noor Zaliha Raja Abdul Rahman ,

  Roles Resources, Supervision, Writing – review & editing

  ¶‡ NDMN, HM and RNZRAR also contributed equally to this work.

  Affiliations Enzyme and Microbial Technology (EMTech) Research Center, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia, Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

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• Yahaya M. Normi

  Contributed equally to this work with: Shaw Xian Au, Azyyati Mohd Padzil, Yahaya M. Normi

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: normi_yahaya@upm.edu.my

  Affiliations Enzyme and Microbial Technology (EMTech) Research Center, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia, Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

  https://orcid.org/0000-0003-0707-7361

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